Caution is warranted with use of potassium citrate in the setting of chronic renal insufficiency or concomitantly with other drugs that may limit renal potassium excretion, such as potassium sparing diuretics
, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists.
Other angiotensin II blockers, potassium sparing diuretics
, heparin, potassium supplements or salt substitutes containing potassium may lead to an increase in serum potassium.
Warnings and Precautions: Monitoring of serum potassium and creatinine levels is recommended during dose titration of Amias in patients with heart failure and regularly in patients taking concomitant ACE-inhibitors and potassium sparing diuretics
such as spironolactone.