So coupling these items with the technological breakthroughs at the time in identifying vast amounts of proteins and their posttranslational modifications
(which are not predicted nor detected from a genome), it's understandable why there was so much excitement to jump start this field.
Acetylation of proteins by HAT/HDAC system using acetyl CoA is among the most widely studied posttranslational modification
and plays an important role in determining cellular responses to variety of damage causing agents.
Bhattacharya said their findings add to a growing realization that posttranslational modifications
such as deimination regulate local dendritic protein synthesis.
It has the limitations of being transparent to proteins that don't contain cysteine (around 8% of all proteins) and that posttranslational modifications
are likely to be missed.
Glycomic studies may reveal glycan changes and provide novel avenues for understanding alcohol's actions, especially on posttranslational modifications
The highest priorities recommended by the workshop were to support studies of structure, analysis, control, and design of conformational and functional states at molecular resolution for environmentally responsive molecules and complexes; promote understanding of dynamics, kinetics, and ligand responses; investigate the mechanisms and steps in posttranslational modifications
, protein partnering, impact of genetic polymorphisms on structure/function, and ligand interactions; and encourage integrated experimental and computational approaches.
It is now well established that long-lived proteins are particularly prone to posttranslational modifications
and that carbamylation contributes to lens ageing and cataracts (21).
We suggest that posttranslational modification
of proANP be investigated, because differences in calibration could lead to different assay performance characteristics for certain populations.
is a point of concern in the development of strategies for proteomics.
Another nonenzymatic posttranslational modification
of proteins is carbamylation, which corresponds to the binding of isocyanic acid to amino groups.
Apparently, O-glycosylation is a unique posttranslational modification
for pro-BNP in this family.
His research interests include determining posttranslational modifications
on EBOV glycoproteins and antiviral strategies for severe virus infections.