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Referring to events that occur after translation.


(pōst′trăns-lā′shə-nəl, -trănz-)
Of or relating to a substance or process, such as the addition of sugar groups to form a glycoprotein, that occurs or is formed after translation of protein: a posttranslational modification.
References in periodicals archive ?
44] Although the exact mechanism underlying tau aggregation is unknown, aberrant posttranslational modification may promote tau aggregation.
This balance depends not only on oxidative stress but also with reductive stress in the myocardium and subsequent posttranslational modification of vital and sensitive cardiac proteins that are involved in the basic function of contractile myocytes.
An intracellular signal transduction cascade, culminating in the activation of Hog1, a yeast homolog of MAPK, conveys stress signal downstream, initiating both posttranslational and transcriptional regulatory events (Mettetal et al.
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.
2011), alterations in posttranslational histone modifications (Kim and Shukla 2005; Pal-Bhadra et al.
Despite many investigations dealing with genetics, proteomics, and posttranslational modifications, we still have not identified targets for improved treatment of these malignancies, and only a few biomarkers have been introduced as prognostic factors.
In fact, biologics are rarely, if ever, limited to a single defined entity; typically, biologics contain a range of discrete molecular entities, differing in posttranslational modifications or other minor structural features.
Posttranslational Hb variants (such as glycated HbSlc) do not separate from the main fractions.
39%); posttranslational modification, protein turnover, and chaperones (10.
A speculation on the source of these antibodies suggests that posttranslational modifications (glycosylation and phosphorylation) of some proteins may create neo-epitopes for the production of autoantibodies (14, 15).
These results suggest that the antiproliferative effect of VACM-1/Cul5 is dependent on its posttranslational modifications and will help in the design of new anticancer therapeutics that target the Nedd8 pathway.
Of these identified proteins, enzyme digestions and chemical oxidation suggest posttranslational modifications of some proteins e.

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