44] Although the exact mechanism underlying tau aggregation is unknown, aberrant posttranslational
modification may promote tau aggregation.
This balance depends not only on oxidative stress but also with reductive stress in the myocardium and subsequent posttranslational
modification of vital and sensitive cardiac proteins that are involved in the basic function of contractile myocytes.
An intracellular signal transduction cascade, culminating in the activation of Hog1, a yeast homolog of MAPK, conveys stress signal downstream, initiating both posttranslational
and transcriptional regulatory events (Mettetal et al.
Differential requirement of CAAX-mediated posttranslational
processing for Rheb localization and signaling.
2011), alterations in posttranslational
histone modifications (Kim and Shukla 2005; Pal-Bhadra et al.
Despite many investigations dealing with genetics, proteomics, and posttranslational
modifications, we still have not identified targets for improved treatment of these malignancies, and only a few biomarkers have been introduced as prognostic factors.
In fact, biologics are rarely, if ever, limited to a single defined entity; typically, biologics contain a range of discrete molecular entities, differing in posttranslational
modifications or other minor structural features.
Hb variants (such as glycated HbSlc) do not separate from the main fractions.
modification, protein turnover, and chaperones (10.
A speculation on the source of these antibodies suggests that posttranslational
modifications (glycosylation and phosphorylation) of some proteins may create neo-epitopes for the production of autoantibodies (14, 15).
These results suggest that the antiproliferative effect of VACM-1/Cul5 is dependent on its posttranslational
modifications and will help in the design of new anticancer therapeutics that target the Nedd8 pathway.
Of these identified proteins, enzyme digestions and chemical oxidation suggest posttranslational
modifications of some proteins e.