postsynaptic density


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postsynaptic density

A microscopic structure within dendritic spines which is associated with the postsynaptic membrane and contains various scaffolding and signalling proteins.
References in periodicals archive ?
Within each synapse is a set of proteins, which, like the components of an engine, bind together to build a molecular machine called the postsynaptic density -- also known as the PSD.
KEY WORDS: [alpha]CaMKII, brain growth spurt, developmental neurotoxicity, field-EPSP recording, hippocampal synaptic plasticity, postsynaptic density.
In additional ex vivo experiments, we investigated protein expression levels in the postsynaptic density (PSD) and catecholamine release from chromaffin cells to further reveal underlying mechanisms.
2+]/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor.
NMDARs and nNOS are coupled together at the postsynaptic membrane through their interaction with postsynaptic density protein (PSD) 95 via PSD-95/disc large/zonula occludens-1 (PDZ) domains.
In this study, we used NMR (nuclear magnetic resonance) spectroscopy and the chemical shift perturbation approach to screen TCM stroke drugs for active components that are capable of binding to the second postsynaptic density 95(PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95, the scaffold protein linking nNOS and PSD-95 at the postsynaptic membrane of neurons (Brenman et al.
This work has characterized the involvement of certain proteins in the postsynaptic density in regulating addictive behaviours, such as NAC-1, Homer and AGS3.