Subsequently, neurotransmitter is released into the synaptic cleft and diffuses to the postsynaptic
membrane to activate neurotransmitter receptors.
The doses of L-dopa needed to control Parkinson's can be quite astronomical, 10,000 to 40,000 mg per day or more to overcome the neurotoxic damage to postsynaptic
The role of dopamine in the modification of the synaptic efficacy only happens when both presynaptic and postsynaptic
neurons are activated.
There is a delicate balance between pre- and postsynaptic
nerve endings and adrenergic prostanoids (particularly PGE), adrenergic stimulation of neurons, endothelium and inducible nitric oxide synthetase (iNOS).
Agonism of postsynaptic
5HT2A receptors by serotonin on dopamine neurons has a direct inhibitory action on the release of dopamine.
Increased calcium within the presynaptic neuron can lead to increased glutamate release into the synapse and increased postsynaptic
neuronal calcium can increase the NMDA signal transduction.
DHA is selectively incorporated into retinal cell membranes and postsynaptic
neuronal cell membranes, where it plays important roles in vision and nervous system function.
2] receptors inhibit release of noradrenaline from the nerve endings and postsynaptic
receptors stimulate [[alpha].
It has been demonstrated by various electrophysiologic studies that snake neurotoxins can result in impairment of presynaptic and postsynaptic
neuromuscular conduction (1-3).
JOSEPH VARGHESE DOHA THREE students of the Weill Cornell Medical College in Qatar (WCMCQ) have written a review article on neurotoxicity titled, 'Metal Toxicity at the Synapse: Presynaptic, Postsynaptic
and Long Term Effects', which has been published in the Journal of Toxicology.
A simple way to think of strengthening a synapse is the insertion of postsynaptic
c) clinical antidepressants act by increasing the reuptake of amines and decreasing their levels at postsynaptic