Current perioperative management of radical cystectomy with intestinal urinaiy reconstruction for muscle-invasive bladder cancer and reduction of the incidence of postoperative ileus
Although it has been previously described in the pediatric population (Table) (4-12), to our knowledge this is the first report of a small bowel intussusception masquerading as a postoperative ileus
in an adult.
A review of the Postoperative Ileus
products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
3,7,67,68] The etiology of postoperative ileus
is multifactoral, with bowel function relying on a combination of the enteric and central nervous systems, hormonal influences, neurotransmitters and local inflammatory pathways.
The cost of postoperative ileus
nationally is estimated to be $750 million to $1 billion a year.
The clinical incidence and effect of postoperative ileus
were quantified in a second report at the meeting.
A review of early experience of 300 patients undergoing the robotic procedure showed a low incidence of surgical complications, the most significant being postoperative ileus
For example, half of the 14% of patients who experienced postoperative ileus
were readmitted for this problem.
Ulimorelin is Tranzyme's intravenous promotility agent in development for the management of postoperative ileus
(POI) in hospital and acute care settings.
These clinical endpoints, time to recovery of upper gastrointestinal function (consumption of solid food) and lower gastrointestinal function (bowel movement), have been accepted by FDA, as approvable endpoints for Adolor Corporation's Entereg(R) (alvimopan) and Progenics Pharmaceuticals' methylnaltrexone for postoperative ileus
associated with opioid analgesics.
Thus, by the time curare was introduced into anaesthesia, there was a known antidote, largely used clinically as a parasympathetic stimulant for postoperative ileus
and urinary retention, but also available for myasthenia gravis.
Previous research has suggested that sham feeding can enhance bowel function by increasing gastric motility and hormone secretion, and one small Japanese study has linked gum chewing to early recovery from postoperative ileus
after laparoscopic colectomy (J.