positive cooperativity

pos·i·tive co·op·er·a·tiv·i·ty

cooperativity in which successive ligand molecules appear to bind with increasing affinity.
References in periodicals archive ?
In ligand-receptor binding kinetics, for example, the equation is strictly valid only for simultaneous binding of all ligand molecules; for the more likely sequential or independent binding schemes, it applies only for strong positive cooperativity [5,6].
While the noise-free Hill coefficient (h) provides a good estimate of the number of binding sites only when there is strong positive cooperativity [5,8] ([beta]<<1 in Eq.
This remarkably high Hill coefficient may imply multiple HXT binding sites exhibiting positive cooperativity.
Palonosetron exhibits allosteric binding and positive cooperativity, unlike granisetron and ondansetron which exhibit simple bimolecular binding and no cooperativity.
When such binding occurs, a conformational change producing positive cooperativity would increase the on-rate of the receptor binding to the fiber.
3), indicating that these two monoclonals have an additive effect and no positive cooperativity.