porphobilinogen synthase


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por·pho·bi·lin·o·gen syn·thase

a liver enzyme catalyzing the formation of porphobilinogen and water from two molecules of δ-aminolevulinate, an important reaction in porphyrin biosynthesis; inhibited by lead in cases of lead poisoning; a deficiency of this enzyme results in elevated levels of δ-aminolevulinate and results in neurologic disturbances.

porphobilinogen synthase

References in periodicals archive ?
New type of hepatic porphyria with porphobilinogen synthase defect and intermittent acute clinical manifestation.
Although aluminum may have a physiological role in the action of a few enzymes, such as succinic dehydrogenase and porphobilinogen synthase, it is typically monitored to evaluate toxicity in patients subjected to hemodialysis for renal failure (3, 4).
Porphobilinogen synthase aminolevulinic acid dehydratase) activity in human erythrocytes: reactivation by zinc and dithiothreitol depending on influence of storage.