porokeratosis

porokeratosis

 [por″o-ker″ah-to´sis]
a rare, chronic, progressive autosomal dominant skin disorder, seen most often in males, usually first appearing in early childhood, and characterized clinically by the presence of craterlike patches that have central atrophy with an elevated thick keratotic border and enlarge to form lesions. adj., adj porokeratot´ic.

po·ro·ker·a·to·sis

(pō'rō-ker'ă-tō'sis),
A rare dermatosis in which there is a thickening of the stratum corneum with an anular keratotic rim or cornoid lamella surrounding progressive centrifugal atrophy; cutaneous carcinoma has been reported to arise in the lesions.
Synonym(s): Mibelli disease
[G. poros, pore, + keratosis]

porokeratosis

/po·ro·ker·a·to·sis/ (por″o-ker″ah-to´sis) a hereditary dermatosis marked by a centrifugally spreading hypertrophy of the stratum corneum around the sweat pores followed by atrophy. Called also p. of Mibelli. porokeratot´ic

porokeratosis

A clonal disorder of cutaneous keratinisation characterised by atrophic patch(es) on the skin surrounded by a hyperkeratotic rim called the cornoid lamella.

Risk factors
Genetic predisposition, exposure to UV light and external beam radiation, immunosuppression (e.g., HIV), lymphoma, iatrogenic related to organ transplantation.

Prognosis
Malignancy develops in 10% of lesions, usually squamous or basal cell carcinomas.

Clinical variants of porokeratosis
• Classic porokeratosis of Mibelli.
• Disseminated superficial actinic porokeratosis (DSAP).
• Porokeratosis palmaris et plantaris disseminata (PPPD).
• Linear porokeratosis.
• Punctate porokeratosis.
• Other variants include hyperkeratosis types, a pruritic papular variant, and a verrucous variant localised to the buttocks which mimics psoriasis.

po·ro·ker·a·to·sis

(pōr'ō-ker'ă-tō'sis)
A rare dermatosis in which there is a thickening of the stratum corneum with an anular keratotic rim or cornoid lamella surrounding progressive centrifugal atrophy; cutaneous carcinoma has been reported to arise in the lesions.
Synonym(s): Mibelli disease.
[G. poros, pore, + keratosis]

Mibelli,

Vittorio, Italian dermatologist, 1860-1910.
Mibelli angiokeratomas - telangiectatic small papules of the extremities, common in adolescent girls.
Mibelli disease - Synonym(s): Mibelli syndrome
Mibelli syndrome - eruption of miliary translucent papules. Synonym(s): Mibelli disease; porokeratosis
References in periodicals archive ?
A Chinese research team, led by Anhui Medical University and BGI, has found the strong genetic evidences of mevalonate kinase gene (MVK) mutations link to disseminated superficial actinic porokeratosis (DSAP).
They did not found MVK mutations in other clinical subtypes of Porokeratosis, suggesting that MVK mutations may be specific to DSAP patients.
The hyperkeratotic variant of porokeratosis Mibelli is a distinct entity: clinical and ultrastructural evidence.
Disseminated bilateral hyperkeratotic variant of porokeratosis Mibelli.
Verrucous porokeratosis of Mibelli on the buttocks mimicking psoriasis.
Laino L, Pala S, Innocenzi D, Accappaticcio G, Van Steensel MA: Genital porokeratosis.
Tangoren IA, Weinberg JM, loffreda M, Werth VP, James WD: Penile porokeratosis of Mibelli.
Porokeratosis is a disorder of abnormal proliferation of keratinocytes that manifests as small atrophic patches surrounded by a ridge-like border or the cornoid lamellae.
The lesion you described is a callus, a wart, or a porokeratosis.
A porokeratosis is similar to a wart but is not caused by a virus.
Elewski, professor and Director of Clinical Research, Department of Dermatology, at the University of Alabama at Birmingham and past president of the American Academy of Dermatology, presented a poster entitled, "Disseminated Superficial Actinic Porokeratosis (DSAP) Treated with Diclofenac Sodium 3% Gel.
Dermatological diseases in which Koebner's phenomenon occurs Contact dermatitis Molluscum contagiosum Darier's disease Pellagra Dermatographism Perforating disorders Eruptive xanthoma Pityriasis rubra pilaris Erythema multiforme Porokeratosis Henoch-Schonlein purpura Psoriasis * Kyrle's disease Reactive perforating collagenosis Lichen nitidus Rhus dermatitis * Lichen planus * Verrucae * Lichen sclerosus et atrophicus Vitiligo * Most frequently seen Table 2.