poor metabolizer

poor metabolizer

Pharmacology A person who metabolizes a probe drug–the rate of which is related to the metabolizing cytochrome P-450 enzyme–slower than others; a person can be a PM of one probe drug, and an extensive metabolizer of another. See Probe drug. Cf Extensive metabolizer.
References in periodicals archive ?
A blood test is used to determine if a person is a poor metabolizer.
se, two possible explanations for the failure of clopidogrel to prevent further cerebrovascular events are that he has a 2C19 genetic variant causing the poor metabolizer phenotype, and/or fluoxetine is inhibiting 2C19 and mimicking the poor metabolizer phenotype.
For example, a poor metabolizer of a CYP2D6 medication will not break a particular drug down at a normal rate.
Pharmacogenomics tests showed CYP2D6*4 homozgyous, corresponding to poor metabolizer as a result of deficient CYP2D6 enzyme.
You need an enzyme to mecabolize it to active compound, so you will gee higher adverse events if you are a rapid mecabolizer and inefficacy if you are a poor metabolizer.
If a patient on fluoxetine tests as a poor metabolizer, "I'd probably prescribe a lower dose, 10-20 mg, if I use the drug at all," Dr.
A poor metabolizer for cytochromes P450 2D6 and 2C19: a case report on antidepressant treatment.
Tests are available to assess CYP2C19 genotype to determine if a patient is a poor metabolizer.
Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype.
RFLP analyses would have erroneously classified the individual as a poor metabolizer.
Fifty-nine percent of drugs most commonly cited in ADR studies are processed by enzymes with genes known to have poor metabolizer variants.
Thus, a patient with ultrarapid CYP2D6 activity might require a higher dose of paroxetine, whereas a poor metabolizer might be exquisitely sensitive to it.