poor metabolizer

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poor metabolizer

Pharmacology A person who metabolizes a probe drug–the rate of which is related to the metabolizing cytochrome P-450 enzyme–slower than others; a person can be a PM of one probe drug, and an extensive metabolizer of another. See Probe drug. Cf Extensive metabolizer.

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metabolizer			The 5%-10% of most populations who lack 2D6 are poor metabolizers of tricyclic antidepressants and typical antipsychotics, whereas those with three or more copies are ultrarapid metabolizers and may not respond to the medications, according to Dr. Pharmacogenomics: clinical utility closer by Walsh, Nancy / Clinical Psychiatry News Some have been withdrawn from clinical use because of their associated side effects such as the occurrence of significant cardiovascular adverse effects including orthostatic hypotension, especially in poor metabolizer subjects. Cytochrome P450 2D6 polymorphism in white Lebanese population by Saade, Sarita; Mroueh, Mohamad; Saab, Yolande / Journal of Applied Research Pharmacogenomics tests showed CYP2D6*4 homozgyous, corresponding to poor metabolizer as a result of deficient CYP2D6 enzyme. Pharmacogenomics and its applications by White, Robert M.; Wong, Steven H.Y. / Medical Laboratory Observer			pontine angle tumor pontine flexure pontine micturition center pontine nuclei pontine nucleus pontine respiratory center Pontius syndrome pontobulbar Pontocaine pontocerebellar pontomedullary pontomedullary groove pontomesencephalic PONV pony Poodle pool Poole suction tube pooled plasma pooled serum poonga oil tree pooper-scooper Poor Man's Ecstasy Poor Man's Pot Poor Metaboliser poor metabolizer poor performance syndrome poor quality roughage Poor Sleep Hygiene Poor Surgical Candidate poorly differentiated poorly differentiated lymphocytic lymphoma poorly differentiated lymphocytic malignant lymphoma poorness Pop Pop the Clot popany vetch Popcorn Popcorn Calcification Popcorn Cell popcorn flower Popcorn Lung Popcorn Plus Diet Pope Popeye Arm Deformity Popeye Syndrome poplar poples popliteal popliteal artery popliteal cyst			Poor Little Rich Girl Poor Little Rich Girl Poor man's copyright Poor Man's Dosing Drops Poor Man's Ecstasy Poor man's grenade Poor man's grenade Poor man's grenade Poor Man's Lift Poor Man's Mustard Poor Man's Navier-Stokes Poor Man's Orange poor man's orchid poor man's orchids Poor Man's Pizza Poor Man's Porsche Poor Man's Pot poor man's pulse Poor Man's Record Poor man's treacle Poor Man's War Poor Man's Watch Forum Poor man's weather glass poor man's weatherglass Poor Man's Whiskey Poor Man's Yacht Club Poor metaboliser poor metabolizer Poor Motivational Syndrome poor mouth poor mouths Poor muscle tone Poor muscle tone Poor muscle tone poor naming Poor News Network Poor Obfuscation Implementation Poor Operating on Packet poor opinion Poor Peasants Groups poor people Poor People’s Economic Human Rights Campaign poor performance syndrome poor person Poor Preplanning Produces Piss Poor Performance Poor Presentation Poor Prior Planning Produces Piss Poor Performance poor prospect Poor Quality Original poor quality roughage poor quality work Poor R Wave Progression Poor R-Wave Progression Poor rate

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