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poor metabolizer

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poor metabolizer
Pharmacology A person who metabolizes a probe drug–the rate of which is related to the metabolizing cytochrome P-450 enzyme–slower than others; a person can be a PM of one probe drug, and an extensive metabolizer of another. See Probe drug. Cf Extensive metabolizer.


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The 5%-10% of most populations who lack 2D6 are poor metabolizers of tricyclic antidepressants and typical antipsychotics, whereas those with three or more copies are ultrarapid metabolizers and may not respond to the medications, according to Dr.
Some have been withdrawn from clinical use because of their associated side effects such as the occurrence of significant cardiovascular adverse effects including orthostatic hypotension, especially in poor metabolizer subjects.
Pharmacogenomics tests showed CYP2D6*4 homozgyous, corresponding to poor metabolizer as a result of deficient CYP2D6 enzyme.
 
 
 
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