The pontine basal nuclei are oriented toward the contralateral cerebellum via the transverse pontine fibers and MCPs, which constitute the pontocerebellar
Hot cross bun sign refers to the cruciform shaped pontine T2 hyperintensity in multiple system atrophy due to selective loss of myelinated transverse pontocerebellar
fibers and neurons in the pontine raphe and sparing of the pontine tagmentum and corticospinal tracts.
Corticospinal tract and pontocerebellar
fiber of central pontine myelinolysis.
This was probably due to Wallerian degeneration and/or to arrested development of the corticospinal and corticobulbar tracts, as well as pontocerebellar
connections, which were well demonstrated by neurofilament immunostaining (Figure 6, C and D).
The characteristic T2 hyper intense sign in pons and middle cerebellar peduncle ("Cross sign") reflects pontocerebellar
fibers degeneration and despite very suggestive of MSA it can be found in other forms of parkinsonism.
Ella has pontocerebellar
hypoplasia which means she can do nothing for herself.
That sentiment was shared by 38-year-old Caerphilly mum Claire Curtis, whose three-year-old daughter Maisie has a rare genetic condition called pontocerebellar
hypoplasia type 2.
Recently there was a study showing that recessive mutations in a subunit of the exosome complex can lead to pontocerebellar
hypoplasia, a rare neurological disorder characterized by impaired development or atrophy of parts of the brain," said Sen.
Once mutations in exosome complex genes are identified in either skin diseases or other diseases like pontocerebellar
hypoplasia, it may be possible to design drugs targeting these defects," he added.
By contrast, pontocerebellar
projection fibers were particularly resistant to HIV effects, as were commissural fibers coursing through premotor and sensorimotor callosal sectors (Pfefferbaum et al.
The Linthorpe youngster was only three months old when he was diagnosed with pontocerebellar
hypoplasia - a rare condition that causes developmental delay and mobility problems.
The nervus intermedius enters the central nervous system at the pontocerebellar
groove lateral to the motor root and synapses with neurons in the upper part of the solitary tract of the medulla oblongata.