Compliance, side effects and complexities of polytherapy
are reasons suggested for these inadequately controlled hypertensives.
0) Female, n (%) 75 (77) 61 (78) Unemployed, n (%) 87 (89) 69 (88) Disability grant (n=97), 23 (24) 17 (22) n (%) School education (years) 10 (9 - 12) 10 (9 - 11) (n=79), median (IQR) Polytherapy
(n=97), n (%) 56 (58) 42 (55) Substance use history 23 (26) 16 (22) (n=88), n (%) HIV status not disclosed 12 (24) 6 (15) (n=51), n (%) WHO stage four (n=88), 62 (71) 49 (71) n (%) Nadir CD4 (cells/[mm.
In comparison with polytherapy
, monotherapy also reduces the potential for adverse drug interactions.
Our unanticipated finding shows that the combination of the two drugs as a part of polytherapy
provides beneficial effects on glucose reduction.
This may be in part dose-dependent, and polytherapy
is typically associated with a higher risk.
However, the clinical benefits of antipsychotic polytherapy
have not been well studied (Centorrino et al.
us], now features a panel discussion of leading experts on the role of rational polytherapy
in the treatment of patients with epilepsy, led by Dr.
Treatment goals vary according to the epilepsy syndrome; seizure control without adverse drug effects may not be achievable in all and inappropriate polytherapy
may lead to unacceptable side-effects without added benefit.
Within the subgroup with WWE risk of malformations were higher for those who were not on antiepileptic drugs and those who were on polytherapy
The most recent studies of antiepileptic drug (AED) response suggest that seizure freedom occurs in less than 4% of patients who fail three AEDs or who are treated with polytherapy
Similar results were found when testing for the use of anti-epileptic drugs in monotherapy (individuals taking only one anti-epileptic drug) and in polytherapy
(individuals taking more than one anti-epileptic drug).
Monotherapy or, if clinically indicated following failure of one or two single AEDs, polytherapy
with a combination of at least two AEDs of different pharmacological mechanisms should be used.