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polysomy

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polysomy /poly·so·my/ (pol´e-so″me) an excess of a particular chromosome.
pol·y·so·my (pl-sm)
n.
The state of a cell nucleus in which a specific chromosome is represented more than twice.

polysomy
[pol′isō′mē]
the presence of more than two copies of a chromosome in an otherwise diploid somatic cell as the result of chromosomal nondisjunction during meiosis. The chromosome may be duplicated three (trisomy), four (tetrasomy), or more times. Males with Klinefelter's syndrome may have a genotype of XXY, XXXY, or XXXXY. Polysomic females with three, four, or five X chromosomes may have a higher frequency of mental retardation.

polysomy [pol″e-so´me]
an excess of a particular chromosome.

polysomy
an excess of the numbers of a particular chromosome present.


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The scoring systems used for increased ploidy are subjective and in many cases it may reflect general genomic instability rather than a specific EGFR gene amplification or chromosomal polysomy.
Also, colorectal tumours distinguishable by fluorescence in situ hybridisation (FISH) analysis of EGFR as homogeneously disomic or with low chromosome 7 polysomy have a reduced response rate to panitumumab [5].
In addition to the diagnostic t(12;22), polysomy of chromosome 8 has been observed as a secondary abnormality in many cases of CCSTA.
 
 
 
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