Polyprenols can be extracted from the green verdure of various conifer and non-conifer species.
The proton NMR spectrum of Ropren [R] substance is in accord with the published data for betulaprenol type polyprenols (lbata etal.
Long chain betulaprenol type polyprenols from the leaves of Gingko biloba.
A comparative study of the effect of the polyprenol preparation ropren from coniferous plants on the key enzymes of the cholinergic and monoaminergic types of nervous transmission.
In HFD-fed hamsters treatment with polyprenols for 7 days orally resulted in significant lowering in TG and TC.
The ethanolic extract, its fractions and the polyprenols did not alter significantly the food intake or body weight in all the above experiments.
Finally, on the basis of the above results it can be concluded that the polyprenols showed significant potential to lower the level of plasma lipid profile followed by a beneficial effect on HDL and its ratio with total cholesterol, in dyslipidemic hamster model, may further be optimized for development of antidyslipidemic drug.
Chloroform-soluble fraction containing active component was subjected to repeated column chromatography, furnished a polyprenol characterized as [C.
8 kg, 230-400 meshes) with benzene as eluent, and gave a polyprenol fraction (16.
Chloroform fraction (active) was standardized using polyprenol 1, by HPLC.
This is the first reported isolation of polyprenol from this plant.