Professor Valentin Fuster, General Director of CNIC, Madrid, and Director of Mount Sinai Heart, New York and leader of the CNIC-Ferrer polypill
project, opened the presentation and highlighted the clinical challenges presented by secondary cardiovascular risks.
The researchers are confident that combining several drugs in one pill will encourage medication to be taken more reliably, but despite also being cheaper, the polypill
remains unlicensed in Britain because aspirin can cause gastric bleeding.
Because mailed education and disease management could be more effective in patients who were prescribed multiple cardiovascular drugs than those who were prescribed a single drug, we conservatively assumed that the effectiveness of each intervention was 50 percent of the base-case estimate when combined with polypill
One of the latest studies suggests giving polypills
to people aged over 50 can help to reduce blood cholesterol and blood pressure, two common risk factors for heart attacks and strokes.
is a layered tablet containing three blood pressure-lowering drugs and a cholesterol-lowering statin.
A group of 84 men and women aged 50 and over were randomly given the polypill
or an inactive "dummy" tablet for a period of three months.
does away with this confusion and so it's hoped it will improve compliance and help prevent people stopping their medication or taking it incorrectly.
Cardiovascular complications of HIV: an overview of risk and a novel approach to prevention-the HIV polypill
The principle of the polypill
is simple--put 5 drugs known to reduce cardiovascular risk into a single pill and give it to middle-aged people to prevent cardiovascular disease.
will eventually come in my view, but it will be some time before the Food and Drug Administration approves a single pill containing five or six drugs to treat two or more conditions.
Based on the reduction in risk factors seen in the trial, Yusuf projected the polypill
could reduce heart disease by 60% and stroke by 50%.
Scientists compared Polycap, a five-drug polypill
, with combinations of its different components to assess effectiveness and safety.