Cite the prevalence of polyoma virus infection in renal transplant recipients.
Identify the diagnostic techniques used to confirm the diagnosis of polyoma virus nephropathy.
Describe the outcome of polyoma virus nephropathy in renal transplant recipients.
Reactivation of polyoma virus type BK is now recognized as one cause of severe renal allograft dysfunction and potential graft loss.
The clinical features associated with polyoma virus in these series included lymphocele, bacterial urinary tract infection, hematuria, CMV infection (Howell et al.
Renal biopsy was part of the differential diagnosis regimen in all series, using either immunohistochemistry or in situ hybridization to identify polyoma virus in the renal tissue.
The two cyclosporine patients were switched to tacrolimus prior to the diagnosis of polyoma virus infection.
There is no specific antiviral agent identified to treat polyoma virus nephropathy noted in the renal transplant literature.
This is probably the major reason that this drug has not been used for treatment in the renal transplant population with polyoma virus nephropathy who already have renal impairment from the virus.
Polyoma virus nephropathy is now a recognized cause of transplant renal dysfunction and allograft loss.