polymyxins


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Related to polymyxins: colistin, Sulfonamides, Polyenes

polymyxins

A group of five POLYPEPTIDE antibiotic drugs active against various GRAM NEGATIVE bacteria. They are used almost exclusively as external applications in ointments and eye and ear drops because of their toxicity if taken internally.
References in periodicals archive ?
Accordingly, and in contrast to colistin and polymyxin B, the NAB compounds are excreted into urine to a significant extent.
Poster F1-3966: "Novel Polymyxin Derivatives are Effective in Treating Peritoneal E.
Colistin and polymyxin B resistances were defined as MIC [greater than or equal to] 4 mg/L (4).
2% were resistant to polymyxin B and colistin, respectively.
Of the PDR isolates, 8 were resistant even to colistin and polymyxin B.
Because of the lack of a standard definition for multi-drug resistance in the literature, we defined multidrug resistance as resistance to all or all but 1 antimicrobial drug class commonly prescribed for treatment of patients with gram-negative infections, with the exclusion of polymyxins (26).
isolates with reduced susceptibility to polymyxins.
The susceptibility to polymyxin B and meropenem were tested by disk diffusion and agar dilution techniques according to NCCLS recommendations (9,10).
Among the five polymyxin B-resistant Acinetobacter spp.
essential oils (EO): MyHN, MyK and MyB, and eight antibiotics (AB): ceftriaxone, gentamicin, ciprofloxacin (CIP), kanamycine, amikacin, tetracycline, chloramphenicol, and polymyxin B (PMB) (Sigma, USA).
The most efficient antibiotic was polymyxin B, while the chloramphenicol and ceftriaxone had the lowest effect, showing no activity against any strain.
For instance, a synergy was demonstrated when ampicillin-sulbactam was combined with a carbapenem, or between meropenem and polymyxin B (Ozseven et al.