polymyxin


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Related to polymyxin: Polymyxin B, neomycin, Polymyxin b sulfate, Polymyxin E

polymyxin

 [pol″e-mik´sin]
a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.
polymyxin B a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa, which may cause septicemia, meningitis, urinary tract infections, and middle ear infections. Toxicity is low but there is sometimes damage to kidney and nerve cells. The route of administration is parenteral, oral, or topical to the ear or eye. Oral preparations are not used for systemic infections because the drug is poorly absorbed from the intestinal tract.

pol·y·myx·in

(pol'ē-mik'sin),
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus), an organism found in water and soils and obtainable as a crystalline hydrochloride; all are polypeptides containing various amino acids and a branched-chain fatty acid, usually (+)-6-methyloctanoic acid. There are several polymyxins, (for example, designated A, B1, C, D, E, M, T), which are about equally effective against gram-negative bacteria, but which differ in toxicity, polymyxin E (colistin) and polymyxin B being the least toxic.
See also: colistimethate sodium.

polymyxin

/poly·myx·in/ (-mik´sin) generic term for antibiotics derived from Bacillus polymyxa; they are differentiated by affixing different letters of the alphabet.
polymyxin B  the least toxic of the polymyxins; its sulfate is used in the treatment of various gram-negative infections.

polymyxin

(pŏl′ē-mĭk′sĭn)
n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.

pol·y·myx·in

(P) (pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa, an organism found in water and soils and obtainable as a crystalline hydrochloride.

pol·y·myx·in

(pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus).

polymyxin (pol´ēmik´sin),

n an antibiotic substance derived from cultures of
B. polymyxa. Used topically, in troche form, in combination with bacitracin and neomycin in the treatment of various oral infections. Not used systemically; therefore sensitization is minimized. Systemic use may be attended by renal dysfunction and toxicity.

polymyxin

a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.

polymyxin B
a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa and is also used against Klebsiella spp. It is used mostly in combinations with other antibiotics as a topical dressing including ophthalmic and aural preparations. It is not absorbed from the alimentary tract and is not recommended for systemic use because of its nephrotoxicity and neurotoxicity.
polymyxin E
References in periodicals archive ?
Genes encoding lipid IVA acyltrasferase (msbB), biofilm formation, antimicrobial peptide resistance (carR), and 3 aminoacyl lipid modification (almEFG) have been shown to contribute to polymyxin resistance in V cholerae (6-8).
The most efficient antibiotic was polymyxin B, while the chloramphenicol and ceftriaxone had the lowest effect, showing no activity against any strain.
The neomycin, polymyxin B sulfate, and bacitracin zinc ophthalmic ointment was discontinued, and an ophthalmic ointment containing polymyxin B sulfate and oxytetracycline hydrochloride (topically OU q12h for 10 days, Terramycin, Pfizer Inc) was started for treatment of the suspected Mycoplasma species conjunctivitis.
At present, only two antibiotic subclasses are still available to treat XDR infections, polymyxins and tigecycline.
Antibiotic Carbenicillin Ampicillin Rifampicin Growth S R I Antibiotic Penicillin Tetracycline Polymyxin B Growth R R S Antibiotic streptomycin Chloramphenicol Growth R I Antibiotic Novobiocin Erythromycin Growth R S
Polymyxin B is the eleventh product approved under the Sagent and Strides Arcolab partnership.
cholerae O1 with typical El Tor phenotypes (resistant to 50 units of polymyxin B, and positive for CCA and VP test) but carrying [ctxB.
Enterobacteriaceae suppression by three different oral doses of polymyxin E in human volunteers.
Northern Antibiotics has developed two series of novel polymyxin (NAB) compounds (Vaara M.
Perfringens Agar OPSP uses a combination of sulphadiazine, oleandoymcin & polymyxin to achieve selectivity, whilst cycloserine is used with the TSC formulation.
It consists of a plastic cylindrical container filled with a special fiber composite immobilized with the antibiotic polymyxin B, which has high affinity for endotoxin.
Following symptomatic treatment with 2% diphenhydramine spray and triple antibiotic ointment (bacitracin, neomycin, and polymyxin B), beginning resolution of the lesions was noted by the same evening, and complete resolution occurred over a week's time.