poly(glutamic acid)

(redirected from polyglutamate)

pol·y(glu·tam·ic ac·id)

(pol'ē-glū-tam'ik as'id),
A polymer of glutamic acid residues in the usual peptide linkage (α-carboxyl to α-amino). See: poly- (2).
See also: poly (γ-glutamic acid).
Synonym(s): polyglutamate
References in periodicals archive ?
Opaxio(TM) (paclitaxel poliglumex, CT-2103), is an investigational, biologically enhanced chemotherapeutic that links paclitaxel, the active ingredient in Taxol, to a biodegradable polyglutamate polymer, which results in a new chemical entity.
Contribution of common polymorphisms in reduced folatecarrier and glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis.
XYOTAX(TM) (paclitaxel poliglumex, CT-2103) is an investigational, biologically enhanced, chemotherapeutic that links paclitaxel, the active ingredient in Taxol(R), to a biodegradable polyglutamate polymer, which results in a new chemical entity.
XYOTAX (Zi-o-taks) is a biologically-enhanced chemotherapeutic that links paclitaxel, the active ingredient in Taxol, to a biodegradable polyglutamate polymer, resulting in a new chemical entity.
The antioxidant molecule vitamin C is known to influence folate synthesis by enhancing formation of the polyglutamate derivatives from tetrahydrofolic acid and enhancing the transformation of folic acid into tetrahydrofolic acid (30).
After introducing the basics of the use of infrahuman animal models for studying human psychiatric disease, they present current research on transgenic and knockout models leading to the analysis of neurocognitive dysfunction, including polyglutamate disorders, mental retardation, speech and language dysfunction, and autism.
It is also better absorbed in the gastrointestinal tract than the naturally occurring food folates, which are reduced polyglutamate derivatives.
Once taken-up by cells, a portion of methotrexate and 7-hydroxymethotrexate is metabolized to polyglutamate derivatives.
XYOTAX (paclitaxel poliglumex) is a pharmaceutical that links paclitaxel, the active ingredient in Taxol(R), to a biodegradable polyglutamate polymer, which results in a new chemical entity.
Cell Therapeutics exclusively licensed its polyglutamate polymer delivery technology from PG-TXL Co.
Further analysis of the data demonstrated a potential correlation between the sensitivity to pralatrexate and the expression level of folyl-polyglutamate synthetase (FPGS), an enzyme that catalyzes the addition of polyglutamate tails to natural folate and antifolates such as pralatrexate.