For instance, the company's steroid 21-hydroxylase antibody (21-0HAb) test kit may be useful as an aid in the diagnosis of autoimmune adrenal disease, whether expressed as autoimmune Addison's Disease or Addison's Disease as part of the more complex autoimmune polyglandular syndrome
(APS), Type I or II.
Key Words: Vitiligo, autoimmune polyglandular syndrome
, autoimune thyroiditis, autoimmune gastritis
Hashimoto disease is observed with a rate of 10% and type 2 DM is observed with a rate of 70% as a component of type 1 autoimmune polyglandular syndrome
Antibodies against the adrenal cortex, thyroid peroxidase, parietal cells, and intrinsic factor were present, establishing the diagnosis of autoimmune polyglandular syndrome
This rare disease goes by a variety of other names including autoimmune polyglandular syndrome
(APS), polyglandular autoimmune syndrome (PGA) and autoimmune polyendocrinopathy syndrome.
The association of chronic mucocutaneous candidiasis, adrenal insufficiency and hypoparathyroidism as components of the autoimmune polyglandular syndrome
type 1 (APS-I) or autoimmune polyendocrinopathy candidiasis-ectodermal dystrophy (APECED) is well recognized.
11) In a subsequent study, 56% of patients with acquired hypoparathyroidism and autoimmune polyglandular syndrome
1 had autoantibodies directed against the extracellular portion of the parathyroid calcium-sensing receptor (CaSR), the autoantigen now suggested to cause parathyroid failure.
To the Editor: In reading the article "Addisonian Crisis Precipitated by Thyroxine Therapy: A Complication of Type 2 Autoimmune Polyglandular Syndrome
," (1) I was reminded of Dr.
VKH syndrome is also associated with other autoimmune disorders, such as autoimmune polyglandular syndrome
type 1, (1) hypothyroidism and diabetes mellitus, (2) and Hashimoto's thyroiditis.
Coverage begins with principles, and growth and maturation, leading into obesity and nutrition, diabetes mellitus, the parathyroid gland, calciotropic hormones, and bone metabolism, and coverage of the thyroid, adrenal gland, and cardiovascular system as well as endocrine changes in critically ill patients, reproductive endocrinology and sexual function, polyglandular syndromes
, and testing.
These five chapters cover Addison's disease, premature ovarian failure, autoimmune hypophysis, and autoimmune polyglandular syndromes
type I and type II.
Topics addressing individual predisposition include basic mechanisms in autoimmunity and contributing or environmental factors, autoimmune thyroid disease, including animal models, autoantigens, Grace's Disease, hypothyroidism, postpartum thyroiditis, ophthalmopathy and dermopathy; Type I diabetes mellitus, including animal models, islet cell autoantigens; other autoimmune endocrinopathy's, including Addison's disease, premature ovarian failure, hypophysitis and autoimmune polyglandular syndromes