polyene antibiotic

polyene antibiotic

A broad-spectrum antifungal produced by Streptomyces spp, eg amphotericin B, nystatin, pimaricin; toxicity may be ameliorated by newer drug delivery systems–eg, liposomes, lipid dispersions, colloidal suspensions
References in periodicals archive ?
Amp B a polyene antibiotic is the second line treatment for leishmaniasis, binds specifically to ergosterol, the main sterol present of Leishmania, trypanosome cruzi and fungi [15].
In the early part of the 20th century gentian violet, an aniline dye was use to treat fungus, but because of resistance and side effects, it was replaced by a polyene antibiotic, and nystatin, was discovered in 1951.
It does not occur with Filipin, another polyene antibiotic.
Self-association of the polyene antibiotic nystatin in dipalmitoylphosphatidylcholine vesicles: a time-resolved fluorescence study.
NYS and other polyene antibiotics activities are characterized by their bonding with ergosterol in the cytoplasm membrane of sensitive fungi.
Nystatin is a widely used polyene antibiotic because it is very active against most pathogenic fungi such as Candida and Aspergillus.
Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group.
The polyene antibiotics, which apparently act by binding to membrane sterols, contain a rigid hydrophobic center and a flexible hydrophilic section.
Although numerous polyene antibiotics have been isolated, only amphotericin B is used systemically.
A major group of drugs that have been approved for the therapy of systemic fungal infections are polyene antibiotics.
Thus, all properties of these compounds in table 2 are not located in definition ranges for polyene antibiotics.
Ergosterol is the site of interaction for polyene antibiotics while azoles interfere with ergosterol synthesis.