polyene


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polyene

 [pol´e-ēn]
1. a chemical compound with a carbon chain of four or more atoms and several conjugated double bonds.
2. any of a group of antibiotic antifungal agents with similar structure, such as amphotericin b, candicidin, or nystatin; they are produced by species of Streptomyces that damage cell membranes by forming complexes with sterols.

pol·y·ene

(pol'ē-ēn),
A chemical compound having a series of conjugated (alternating) double bonds; for example, the carotenoids.

polyene

/pol·y·ene/ (pol´e-ēn)
1. a chemical compound with a carbon chain of four or more atoms and several conjugated double bonds.
2. any of a group of antifungal antibiotics with such a structure (e.g., amphotericin and nystatin) produced by species of Streptomyces that damage cell membranes by forming complexes with sterols.

polyene

1 a chemical compound with a carbon chain of four or more atoms and several conjugated double bonds.
2 any of a group of antibiotic, antifungal agents with similar structure, such as Amphotericin B or Nystatin; they are produced by a species of Streptomyces that damage cell membranes by forming complexes with sterols.

polyene

chemical compound characterized by the presence of several conjugated double bonds.

polyene antibiotics
a group of agents, synthesized by Streptomyces spp., with antifungal activity; includes amphotericin B, nystatin and candicidin.
References in periodicals archive ?
In a paper published in 2014 in the journal Nature Chemistry, Burke showed that most of the motifs of a class of compounds called polyenes could be made from just 12 basic building blocks by repeating a simple chemical reaction.
Among all the drugs for liver disease, polyene phosphatidyl choline is the natural diglyceride of cholinephosphoric acid and unsaturated fatty acids which can protect hepatocyte from lesion, alleviate inflammation reaction and improve the detoxification of the liver.
Transport through liquid membrance bilayers generated by lecithin, cholesterol and lecithin-cholesterol mixtures-studies in the presence of polyene antibioties.
5) Amphotericin is a polyene macrolide that binds preferentially to ergosterol in the fungal cell membrane; it also binds human cholesterol.
Alternative treatments for visceral Leishmanisis include the polyene antibiotic amphotericin B that has highly effective less toxic lipid formulations (Sundar 2003).
Key statement: A crosslinkable and crosslinked organosilicon polymer which is prepared from a mixture of a reactive polysiloxane resin having both reactive carbon-carbon double bonds and silicone-hydrogen groups, characterized by alternating structures of polycyclic polyene residue and cyclic (or tetrahedral) polysiloxane residue, and either vinyl terminated fluorine-containing polysiloxane or vinyl terminated phenyl-substituted siloxane.
The alternative double bonds and conjugation in the polyene compounds are one of the main properties in these compounds.
The active medium consists of diarylalkene derivatives, triene derivatives, or polyene derivatives.
Structure of fatty acids and lipids: Introduction; Fatty-acid nomenclature; Fatty acids--main structural features; Saturated acids; Monoene acids; Methylene-interrupted polyene acids; Other unsaturated acids; Branched chain and cyclic acids; Oxygenated acids; Halogenated fatty acids; Introduction to lipid structure; Acylglycerols; Wax esters; Glycosyldiacylglycerols; Phospholipids; Ether lipids; Sphingolipids.
Additionally, Congo red, anthracyclines, dimethyl sulfoxide, glycerol, and polyene antibiotics have some degree of activity in vitro or in experimental animals (6).
Studies that have included antifungal susceptibility testing have demonstrated that B capitatus is usually sensitive to the polyene amphotericin B (minimum inhibitory concentration [MIC], 0.