polyclonal immunoglobulin

polyclonal immunoglobulin

Polyclonal antibody Immunology Any of a bouquet of Igs produced by multiple, usually non-malignant clones of cells summoned to arms by an immune challenge, which may evoke multiple clonal expansions, each responding to a different epitope on an antigen or group of antigens. See Epitope, Idiotype. See Polyclonal antiserum. Cf Monoclonal antibody.
References in periodicals archive ?
We propose that the definition of STSS extends beyond that of a condition exclusive to GAS infection and recommend that polyclonal immunoglobulin be considered as a potentially lifesaving adjunctive therapy.
Polyclonal immunoglobulin free light chains as a potential biomarker of immune stimulation and inflammation.
1,2,4,5,8) Samples with increased polyclonal immunoglobulin concentrations have not been reported to exhibit interference.
14-16 According to the International Guidelines for Management of Severe Sepsis and Septic Shock in 2008, there is a grade 2C recommendation for the use of polyclonal immunoglobulin in paediatric sepsis syndrome.
3) The HMS is presented as an exaggerated immune response to infection by Plasmodium, resulting in nonspecific, hyper-immunoglobulin M (IgM) polyclonal immunoglobulin production by B lymphocytes, and the formation of immune complexes that are deposited in the spleen.
Following the "total" immunoglobulin class within which the monoclonal protein falls may be misleading when there are alterations in the concentrations of polyclonal immunoglobulin.
When there is increased polyclonal immunoglobulin production and/or renal impairment, both is and [kappa] FLC concentrations can increase 10- to 20-fold.
The detection limits of the IFE assay for monoclonal proteins are 25-50 mg/L, depending on the position of the monoclonal protein band and the content of polyclonal immunoglobulin.
Results of IS-CE are particularly difficult to interpret in cases with a high polyclonal immunoglobulin background and in cases where small peaks comigrate with other peaks.
2]-microglobulins; however, in the present case this was not true because of a lack of polyclonal immunoglobulin synthesis.
Multiple myeloma is a hematologic malignancy characterized by proliferation of a neoplastic plasma cell population that usually leads to abundant production of a monoclonal immunoglobulin, also called paraprotein or M-protein, as well as decreased concentrations of normal polyclonal immunoglobulins.
The addition of polyclonal immunoglobulins to the standard therapy appears to improve significantly the prognosis in patients with severe sepsis.