polyclonal immunoglobulin

polyclonal immunoglobulin

Polyclonal antibody Immunology Any of a bouquet of Igs produced by multiple, usually non-malignant clones of cells summoned to arms by an immune challenge, which may evoke multiple clonal expansions, each responding to a different epitope on an antigen or group of antigens. See Epitope, Idiotype. See Polyclonal antiserum. Cf Monoclonal antibody.
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Based on nine patients enrolled to date, study authors observed that treatment with TACI-Ig reduced circulating polyclonal immunoglobulin levels and had an acceptable tolerability profile with few treatment-related adverse events in these patients.
In accord with the expected TACI-Ig mode of action, polyclonal immunoglobulins decreased significantly during treatment with TACI-Ig.
Following the "total" immunoglobulin class within which the monoclonal protein falls may be misleading when there are alterations in the concentrations of polyclonal immunoglobulin.
Yet, these tests are not quantitative in the strictest sense; they require skilled interpretation and cannot assess immune suppression of polyclonal immunoglobulins of the same isotype as the monoclonal immunoglobulin.
It is directed at the use of polyclonal immunoglobulin Fab fragments in three distInct circumstances, Including their general use in medicine.
When there is increased polyclonal immunoglobulin production and/or renal impairment, both is and [kappa] FLC concentrations can increase 10- to 20-fold.
The detection limits of the IFE assay for monoclonal proteins are 25-50 mg/L, depending on the position of the monoclonal protein band and the content of polyclonal immunoglobulin.
Results of IS-CE are particularly difficult to interpret in cases with a high polyclonal immunoglobulin background and in cases where small peaks comigrate with other peaks.
2]-microglobulins; however, in the present case this was not true because of a lack of polyclonal immunoglobulin synthesis.
Multiple myeloma is a hematologic malignancy characterized by proliferation of a neoplastic plasma cell population that usually leads to abundant production of a monoclonal immunoglobulin, also called paraprotein or M-protein, as well as decreased concentrations of normal polyclonal immunoglobulins.
1B shows a low-concentration M-component superimposed on a diffuse background of polyclonal immunoglobulins.