polyclonal gammopathy


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Related to polyclonal gammopathy: Monoclonal gammopathy

pol·y·clo·nal gam·mop·a·thy

a gammopathy in which there is a heterogeneous increase in immunoglobulins involving more than one cell line; may be caused by any of a variety of inflammatory, infectious, or neoplastic disorders.

polyclonal gammopathy

pol·y·clo·nal gam·mop·a·thy

(pol'ē-klō'năl gă-mop'ă-thē)
A gammopathy in which there is a heterogeneous increase in immunoglobulins involving more than one cell line; can be caused by a variety of inflammatory, infectious, or neoplastic disorders.

gammopathy

abnormal proliferation of the B lymphocytes resulting in abnormal levels of immunoglobulin production; the gammopathies include multiple myeloma, macroglobulinemia and Hodgkin's disease. Called also gammaglobulinopathy.

monoclonal gammopathy
an increased production of one type of immunoglobulin by a single clone of cells. The abnormal protein produced is called paraprotein or M component and may be composed of whole immunoglobulin molecules or subunits, light-chains (Bence Jones proteins) or heavy-chains. Occurs in myelomas, lymphoproliferative neoplasms, and occasionally chronic inflammatory or immune-mediated diseases. Greatly elevated serum levels of protein may result in a hyperviscosity syndrome.
polyclonal gammopathy
a hypergammaglobulinemia resulting from an increased production of several different immunoglobulins and usually attributable to persistent, high level exposure to antigens; occur in a wide variety of infectious, inflammatory, and immune-mediated diseases. Examples in animals are feline infectious peritonitis, canine ehrlichiosis, Aleutian mink disease and equine infectious anemia.

polyclonal

derived from different cells; pertaining to several clones.

polyclonal antiserum
see polyclonal antibody.
polyclonal gammopathy
see polyclonal gammopathy.
References in periodicals archive ?
1) SPEP patterns Normal 20/l02 (19%) 71/228 (31%) Polyclonal gammopathy 52/l02 (51%) 42/228 (18%) Oligoclonal bands 34/l02 (33%) 31/227 (14%) Monoclonal gammopathy 8/l02 (8%) 37/228 (16%) (2.