One of a group of ameboid, mononucleated, wandering phagocytic cells found in inflammatory exudates.
[poly- + G. blastos, germ]
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If their granules scatter in the protoplasm of the phagocytic polyblast, such cells can easily be mistaken for myelocytes.
After their emigration out of the blood vessels into the tissue, they rapidly hypertrophy and join the polyblasts of local origin in their further transformations.
No evidence could be found in the experiments of Maximow of a participation of the endothelium of the blood vessels in the formation of polyblasts.
As we were interested in the origin of the polyblasts (mononuclear exudate cells) in acute aseptic inflammation, only early stages of the process were to be cared for.
However, we repeated the experiments of Foot with the special purpose of solving the question of the origin of the mononuclear exudate cells, the polyblasts, in inflammation.
He has also pointed out that this scarcity of the emigration pictures of nongranular leukocytes, which has been looked on as one of the strong proofs against the hematogenous origin of the polyblasts, pertains equally to the special granulated leukocytes whose hematogenous origin cannot be doubted.
The hypertrophy of the emigrating lymphocytes and monocytes, which began, as we have seen, while the cells were still in the lumen, continues after their migration into the tissue; in this way the emigrated nongranulated blood leukocytes transform themselves into polyblasts (Figs.
In somewhat later stages one can follow the gradual transformation of these mobilized histiocytes into large ameboid phagocytic cells, the histogenous polyblasts (Fig.
Lymphoid, nongranulated wandering cells (with round compact, nonpolymorphous nucleus), polyblasts or mononuclear exudate cells, are now also numerous in the inflamed tissue, and their number continues to increase (Figs.
According to Foot,(4) in the stages under consideration we should expect to find the transformation of the endothelial cells of the blood capillaries into polyblasts in full swing.
the lymphocytes and monocytes, on one hand, and the polyblasts, the "mononuclear exudate cells" outside the vessels, in the tissue, on the other hand, are morphologically similar in every respect (Figs.
Role of endothelium in the production of polyblasts (mononuclear wandering cells) in inflammation.