polyadenylation


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pol·y·ad·e·nyl·a·tion

(pol'ē-ad'ĕ-nil-ā'shŭn),
1. The process of formation of poly(adenylic acid).
2. The covalent modification of a macromolecule (for example, mRNA) by the formation of a polyadenylyl moiety covalently linked to the macromolecule.

polyadenylation

The process by which a sequence of polyadenylic acids (adenosine ribonucleotides) is added to the end of a spliced RNA after its transcription from DNA, resulting in mature mRNA. This addition on the RNA molecule is sometimes referred to as a poly-A tail, and commonly contains several-hundred bases.

polyadenylation

addition of a sequence of ADENINE NUCLEOTIDES to the 3′-end of most eukaryotic RNA molecules, after their TRANSCRIPTION. The sequence is often called a.poly(A) tail.

polyadenylation

the addition of up to 250 adenylate residues to the 3′ end of eukaryotic mRNAs to form a so-called poly(A) tail. The primary transcript is cleaved by a specific endonuclease that recognizes the sequence AAUAAA which is also referred to as a polyadenylation signal sequence. The poly(A) tail protects the mRNA from digestion with nuclease and greatly increases the efficiency of translation.
References in periodicals archive ?
This region was part of the 3' untranslated region (UTR) and was replaced with a KpnI restriction site followed by an SV40 polyadenylation signal.
Presolicitation: Laboratory testing to assess alternative polyadenylation on lung cancer samples from the nci-md case control study sequencing the 3utr of 110 normal tissues and 110 cancer tissues
Enrichment and efficient screening of ES cells containing a targeted mutation : The use of DT-A gene with the polyadenylation signal as a negative selection maker.
is an inhibitor of polyadenylation associated with the stability of mRNA and cell survival (Imesch et al.
This process is called polyadenylation," said Dr de Moor.
Compound heterozygosity for HbD Punjab and polyadenylation signal mutation causes clinically asymptomatic mild hypochromia and microcytosis.
The increase in glycolysis can activate glyceraldehyde 3 phosphate dehydrogenase which gets translocated to the nucleus after polyadenylation.
He found that in the sea slug Aplysia californica, which has long been favored by neuroscientists for memory experiments because of its large, easily-studied neurons, a synapse-maintenance protein known as CPEB (Cytoplasmic Polyadenylation Element Binding protein) has an unexpected property.
The variant found in the present study is an unusual type of mutation that appears to affect the way the gene's messenger RNA is processed; the messenger RNA in patients with the mutant TP53 gene appears to lack proper termination and polyadenylation.
The stop codon (TAG) and one putative polyadenylation signal site were recognized in the 3' untranslated region, which were followed by a short polyA tail (27 bp).