polyadenylation


Also found in: Encyclopedia, Wikipedia.

pol·y·ad·e·nyl·a·tion

(pol'ē-ad'ĕ-nil-ā'shŭn),
1. The process of formation of poly(adenylic acid).
2. The covalent modification of a macromolecule (for example, mRNA) by the formation of a polyadenylyl moiety covalently linked to the macromolecule.

polyadenylation

The process by which a sequence of polyadenylic acids (adenosine ribonucleotides) is added to the end of a spliced RNA after its transcription from DNA, resulting in mature mRNA. This addition on the RNA molecule is sometimes referred to as a poly-A tail, and commonly contains several-hundred bases.

polyadenylation

addition of a sequence of ADENINE NUCLEOTIDES to the 3′-end of most eukaryotic RNA molecules, after their TRANSCRIPTION. The sequence is often called a.poly(A) tail.

polyadenylation

the addition of up to 250 adenylate residues to the 3′ end of eukaryotic mRNAs to form a so-called poly(A) tail. The primary transcript is cleaved by a specific endonuclease that recognizes the sequence AAUAAA which is also referred to as a polyadenylation signal sequence. The poly(A) tail protects the mRNA from digestion with nuclease and greatly increases the efficiency of translation.
References in periodicals archive ?
The structure and location of sequence motifs associated with the initiation of transcription and polyadenylation signal for the mGH gene are not significantly different from the findings in other mammals (Barta et al.
Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs.
Similar results have been achieved using the parotid secretory protein as the promoter and the bovine/swine growth hormone polyadenylation signal as the termination sequence (Yin et al.
CBC also participates in 3' polyadenylation and nucleocytoplasmic transport of mRNA.
1] Normal PABN1 is a nuclear protein that is involved in the polyadenylation of messenger RNA.
is an inhibitor of polyadenylation associated with the stability of mRNA and cell survival (Imesch et al.
TEs specifically signal for the biogenesis of many lncRNAs, including 30,000 unique sites for transcription initiation, splicing, or polyadenylation in humans.
Putative polyadenylation signals in nuclear genes of higher plants: A compilation and analysis.
This process is called polyadenylation," said Dr de Moor.
Bell DA, Badawi AF, Lang NP, Ilett KF, Kadlubar FF, Hirvonen A: Polymorphism in the N-acetyltransferase 1 (NATI) polyadenylation signal: association of NATI*10 allele with higher N-acetylation activity in bladder and colon tissue.