poliovirus vaccine


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poliovirus vaccine

a vaccine prepared from poliovirus to confer immunity to it. The inactivated poliovirus vaccine (IPV) is a suspension of three strains of polioviruses that have been inactivated in formalin so that normal activity of the organisms has been destroyed. IPV is given subcutaneously at 2 mo, 4 mo, between 6 and 18 mo, and between 4 and 6 yr, and is the form of vaccination recommended in the United States. A trivalent live oral form of vaccine, TOPV, rarely causes vaccine-associated paralysis after administration. This reaction has not occurred with IPV and is the reason that use of TOPV is being discontinued in the United States. TOPV is, nevertheless, the treatment of choice in areas of the world where polio is still endemic. Also called poliomyelitis vaccine; poliovirus vaccine, inactivated; Salk vaccine.

poliovirus vaccine, inactivated

po·li·o·vi·rus vac·cine

(pō'lē-ō-vī'rŭs vak-sēn')
1. Inactivated poliovirus vaccine (IPV), an aqueous suspension of inactivated strains of poliomyelitis virus (types 1, 2, and 3) used by injection.
2. Oral poliovirus vaccine (OPV), an aqueous suspension of live, attenuated strains of poliomyelitis virus (types 1, 2, and 3) given orally for active immunization against poliomyelitis.
References in periodicals archive ?
BeyondPolio is focused on both reducing the cost and facilitating the use of the inactivated poliovirus vaccine (IPV), developed by Jonas Salk and his colleagues, to help in the final stages of the global polio eradication effort.
In addition, to detect mutant and recombinant poliovirus vaccine strains, a vaccine-derived, real-time screening assay was performed (David Kilpatrick, pers.
The immunization of infants, children and adults with poliovirus vaccine started in the late 1950's, initially with the Salk inactivated poliovirus vaccine (IPV) and then the Sabin oral poliovirus vaccine (OPV), virtually eliminating poliomyelitis in the United States during the ensuing decades.
Will India need inactivated poliovirus vaccine (IPV) to complete polio eradication?
Inactivated poliovirus vaccine is not routinely recommended for adults living in the United States; however, it is recommended for unimmunized adults in close contact with a child receiving oral polio vaccine (OPV, which is not available in United States) or who have an increased risk of exposure to OPV or wild poliovirus.
health officials: While the injectable, inactivated poliovirus vaccine (the newest, enhanced version is known as E-IPV) carries with it no risk to individuals, it also fails to "donate" protection to other members of society.
OTCBB: BJCT), a leading developer of needle-free injection therapy systems, today announced that Bioject's needle-free injection delivery technology was used to successfully demonstrate that intradermal administration of fractional doses of inactivated poliovirus vaccine given to infants is safe and effective (using seroconversion as an indication of effectiveness), and is preferred by both health care administrators and parents over typical full-dose needle and syringe.
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To the Editor: The World Health Organization Polio Eradication Initiative has reduced to 4 the number of countries with endemic transmission of wild polioviruses and has reported the widespread circulation of polioviruses that have evolved from attenuated vaccine (oral poliovirus vaccine [OPV]), so-called vaccine-derived polioviruses (VDPVs) (1,2).
Protective efficacy of a monovalent oral type 1 poliovirus vaccine.
Will containment of wild poliovirus in laboratories and inactivated poliovirus vaccine production sites be effective for global certification?