Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Idioms, Encyclopedia, Wikipedia.

physician office laboratory

A diagnostic lab in a physician’s office with an abbreviated menu of tests that can be performed while the patient is in the office, so the physician can better manage the patient.

HIV-1 gene

Any of the genes present in the human immunodeficiency virus. See AIDS.
HIV genes
art/trs gene rev gene, see there.
env gene Encodes viral coat proteins gp 120 and gp 41, which mediate CD4 binding and membrane fusion, controlled by tat and rev
gag gene Encodes nucleocapsid core proteins including p24
nef gene 3´ orf, B gene, ORF-2 gene Encodes a protein of unknown function found in infected Pts that may down-regulate viral expression–nef deletion results in a five-fold increase in viral DNA synthesis and replication
pol gene Encodes reverse transcriptase, protease, integrase and ribonuclease
R gene Encodes TAR–transcription activating response element, which has a nonspecific immunodeficiency effect
rev gene art/trs gene Encodes a 19 kD post-transcriptional protein regulator required for HIV replication, up-regulating HIV synthesis by transactivating anti-repression, ↑ levels of envelope RNA by regulating the env gene; inactivation of rev prevents viral replication–as measured by the successful production of the p24 glycoprotein by infected monocytes can be massively ↑ by adding cytokines to culture medium
tat gene Encodes a potent 14 kD transcription activator that amplifies HIV replication, the inactivation prevents viral replication
vif gene Facilitates infectivity of free HIV
vpr gene Encodes a weak transcription activator
vpu gene Unique to HIV-1, encodes a 16 kD product which, when mutated, has a 5-10-fold Ø in replicative capacity and is critical for efficient budding of virions NEJM 1991; 324:308rv
†Gene encoding regulatory protein
‡Gene encoding structural protein


Abbreviation for physician office laboratory.


A viral gene which, in retroviruses, acts in conjunction with the gag gene to direct the formation of gag-pol messenger RNAs.
References in periodicals archive ?
The company also offers a small wall-mount enclosure for a 1-32 splitter for enterprises that require some additional ports after the initial POL installation.
It was at this gathering of potential suicide bombers, comrade Tof chose to announce that he rejected the report, and that Pol had overstepped his mandate.
He said he knows Pol Pot's name, but he doesn't who he was or how powerful and brutal he was.
Foster and Layton studied the Pol IV expression patterns of 24 experimental strains of E.
Exploration/Development Leases: POL is presently operating nine Development and Production leases i.
In the second role, pol [Iota] could also prevent misrepair of GT mismatches.
The latest name-bearer belongs to Charles Hamer, whose wife Marthe was born a Pol Roger and whose late father Peter, a long-serving secretary to the Jockey Club stewards, was commanding officer in the 11th Hussars to Nicholas Soames, Churchill's grandson.
Thai army experts, Pol Pot's comrades and wife, and other persons who had seen him in the past year, all agreed the body cremated yesterday was that of the communist guerrilla.
Guerrillas carried Pol Pot's corpse to its makeshift pyre opposite the wooden shack where it had been displayed to the world.
However, there is significant disagreement on what fate should befall Pol Pot's close associates and commanders.
Then again, you may have directly invited a surveyor to your POL by independently signing up for JCAHO's laboratory accreditation.
COLA is also developing topic-specific fact sheets for distribution via FAX or mail and is reviewing CDC training videos to recommend how they can best be adapted and repackaged for POL use.