podophyllotoxin


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Related to podophyllotoxin: etoposide, podophyllin, Imiquimod, Podofilox

podophyllotoxin

 [pod″o-fil″o-tok´sin]
a highly toxic compound that is the main active component of podophyllum resin and has cathartic and caustic properties. Some of its less toxic derivatives, such as etoposide and teniposide, are used as antineoplastic agents.

pod·o·phyl·lo·tox·in

(pod'ō-fil'ō-tok'sin),
A toxic polycyclic substance with cathartic properties present in podophyllum; has antineoplastic action.

podophyllotoxin

(pŏd′ə-fĭl′ə-tŏk′sĭn)
n.
A toxic polycyclic substance having cathartic properties and antineoplastic activity.

podophyllotoxin

[pō′dōfil′ətok′sin]
Etymology: Gk, pous + phyllon, leaf, toxikon, poison
any one of a group of substances derived from the roots of Podophyllum peltatum, a common plant species known as mayapple or American mandrake. Podofilox, a derivative, is prescribed in the topical treatment of condyloma acuminatum and other types of warts. Several podophyllotoxin derivatives have been used as purgatives and studied for their antineoplastic effects, including the inhibition of mitosis. Podophyllotoxins are not recommended for use in early pregnancy.

podophyllotoxin

podophyllin resin.
References in periodicals archive ?
Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species which is again an antitumor agent (57-59).
Antitumor Activity of a Novel Podophyllotoxin Derivative (TOP-53) Against Lung Cancer and Lung Metastatic Cancer.
One well-studied lignan, podophyllotoxin, is so effective at targeting cancer cells for destruction it has been modified for use in chemotherapy.
For example, ginsenoside from Panax gingseng, rosmarinic acid from Coleus blumei, shikonin from Lithospermum erythrohizon, diosgenin from Dioscorea, ubiquinone-10 from Nicotiana tabacum, berberin from Coptis japonica, and podophyllotoxin from Juniperus chinensis all accumulated at much higher levels in cultured cells than in intact plants (Misawa et al.
Washington, September 6 (ANI): A common weed called American mayapple has been found to produce anti-cancer compound podophyllotoxin, say researchers at Mississippi State University and the University of Mississippi.
For example, Mayapple (a forest herb) contains the chemical podophyllotoxin, which seems useful in treating skin cancer (Mayapple in the wild may be the only source of this chemical).
Recurrence rates for sole therapy with imiquimod (9%-19%) are substantially lower than for most other genital wart treatments, including podophyllotoxin.
Scientists have found the mayapple is an excellent source of podophyllotoxin, a compound used for making cancer-fighting chemicals.
There is an extensive literature that deals with substances like colchicine, steganacin, maytansine, podophyllotoxin, vinblastine, taxol, etc.
Limited Tenders are invited for Podophyllotoxin (pharmaceutical grade 50gm/vial, (qty.
Systematic investigations revealed that the active chemical component of the plant is podophyllotoxin.
As a positive control podophyllotoxin was used; the results were published previously by Och et al.