pluripotency


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Related to pluripotency: Stem cells, Unipotency, Induced pluripotent stem cells

pluripotency

/plu·rip·o·ten·cy/ (-po´ten-se)
1. the ability to develop or act in any one of several possible ways.
2. the ability to affect more than one organ or tissue.plurip´otentpluripoten´tial
References in periodicals archive ?
The capacity for self-renewal and the pluripotency of ESCs is known to be controlled by the transcription factors, Nanog homeobox (NANOG), octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2), and signaling pathways like leukemia inhibitory factor (LIF)-signal transducer and activator of transcription 3 (STAT3) and bone morphogenic protein (BMP)-Mothers against decapentaplegic homolog (SMAD) 1/4/5/8 (Rodda et al.
Stimulus-triggered acquisition of pluripotency (STAP) without the need for nuclear transfer or the introduction of transcription factors has recently been demonstrated by scientists.
In one of her teams studies, Obokata concluded that by moderately lowering the PH level of the cell culture for less than 30-minutes, the pluripotency gene became further expressed in a portion of the cells.
29 in the journal Nature detailed research showing success with a process called stimulus-triggered acquisition of pluripotency, or STAP.
Certain stem cells can be easily grown in the laboratory and can turn into any type of cell in the body, which is called pluripotency.
Haruko Obokata, 30, stating that the young women had shown great talent and initiative in discovering the new phenomenon, known as stimulus-triggered acquisition of pluripotency (STAP).
Even though hESCs have been studied extensively over the last decade due to their potential to differentiate into cell-types of potential clinical applications, little is known about the role that splicing plays in the regulation of pluripotency in these cells.
The products provide consistent high cell viability while maintaining cell pluripotency after a freeze-thaw cycle.
We confirmed pluripotency of ciPSCs using the following techniques: (i) immunostaining and quantitative PCR for the presence of pluripotent and germ layer-specific markers in differentiated ciPSCs; (ii) microarray analysis that demonstrates similar gene expression profiles between ciPSCs and canine embryonic stem cells; (iii) teratoma formation assays; and (iv) karyotyping for genomic stability.
Shinya Yamanaka after he found four genes that determine the pluripotency, and got reprogram adult cells and turn them into iPS.
This was achieved in ground-breaking studies in 2006/7 by Takahashi and Yamanaka, who showed that the ectopic expression of four key embryonic regulatory genes (Oct3/4, Sox2, Klf4 and c-Myc) reactivates endogenous pluripotency genes in mouse and human fibroblasts.