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Related to pleiotropically: Negative pleiotropy


the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen.


/plei·ot·ro·pism/ (pli-ot´rah-pizm) pleiotropy.


a state in which one gene affects two or more aspects of the PHENOTYPE that are apparently unrelated. For example, the ‘vestigial wing’ mutation of Drosophila not only controls the size and shape of the wings but also affects several other features, including reduced FECUNDITY.

pleiotropism, pleiotropy

the production by a single gene of multiple phenotypic effects.
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References in periodicals archive ?
Obviously, this locus pleiotropically affects the macroenvironmental plasticity of these two traits.
The correlation among populations in life-history divergence and reproductive isolation raises the possibility that divergence in some life-history trait(s) has contributed pleiotropically to hybrid inviability.
9 d in 1995, pleiotropically reducing 1994 and 1995 yield grand mean by 265 and 311 kg [ha.
In the other class of model, deleterious mutations pleiotropically affect the values of the quantitative characters measured, although the characters are themselves neutral, and this produces the appearance of stabilizing selection (Barton 1990; Kondrashov and Turelli 1992).
Given the close relationships among some malting quality traits (Burger and LaBerge, 1985), it seems logical that a single QTL might affect several traits pleiotropically.
Partridge and Fowler (1992) suggested that early fecundity differences might have increased life span, not by causing accelerated or delayed senescence but by pleiotropically causing instantaneous age-independent effects (see also Finch 1990, p.
Cross 2 segregated for the dtl allele that confers determinate growth habit and subsequently pleiotropically affects final height and yield (Bernard, 1972; Saindon et al.
Genetic differences in the timing of cercarial shedding that determine host preference contribute pleiotropically to the establishment of an assortative-mating system with early-emerging schistosomes, tending to return and reproduce in a human host, and late-emerging schistosomes, tending to return and mate in a murine host.
According to the modern synthesis, speciation occurs because of gradual divergence in reproductive characters pleiotropically linked to ecologically important traits (Dobzhansky 1937; Huxley 1942; Simpson 1953; Mayr 1963).
Therefore, the wp locus may potentially be linked or pleiotropically influence protein QTL that are highly conserved among members of the Glycine subgenus soja (Moench) F.
For example, development time and senescence rate may be linked pleiotropically, so that shorter development time may imply more rapid senescence.
When the major dwarfing genes were introduced into wheat breeding programs, it was found that the dwarfness they caused was associated pleiotropically with increased grain yield and decreased straw yield.