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pleiotropism
(redirected from pleiotropic)

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pleiotropism /plei·ot·ro·pism/ (pli-ot´rah-pizm) pleiotropy.
plei·ot·ro·pism (pl-tr-pzm) or plei·ot·ro·py (-p)
n.
The control by a single gene of several distinct and seemingly unrelated phenotypic effects.

pleio·tropic (pl-trpk, -trpk) adj.

pleiotropy [pli-ot´rŏ-pe]
the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen.

pleiotropism, pleiotropy
the production by a single gene of multiple phenotypic effects.


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Indeed, the compounds that activate PPAR-[alpha] are pleiotropic and have been reported to exhibit a diversity of responses in addition to the hallmark effect of peroxisome proliferation, including genotoxicity (reviewed by Melnick 2001), epigenetic alterations (e.
These effects are referred to as pleiotropic effects and may influence the biology of atherosclerosis by modulating immunoregulation, inflammation, coagulation and vasomotor responsiveness independent of changes in LDLC.
Lipid-modifying and pleiotropic effects of gemfibrozil, simvastatin and pravastatin in patients with dyslipidemia.
 
 
 
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