platelet transfusion refractoriness

platelet transfusion refractoriness

A failure of circulating platelet levels to rise after platelet transfusion. Alloimmunization against platelet antigens, disseminated intravascular coagulation, fever, hypersplenism, and sepsis are among the potential causes. A typical platelet transfusion should normally raise platelet counts by more than 20,000 platelets/microliter.
References in periodicals archive ?
rFVIIa is effective for severe bleeding in Glanzmann thrombasthenia patients, especially in those with antiplatelet antibodies and/or platelet transfusion refractoriness.
Platelet transfusion refractoriness associated with HPA-1a (PlA1) alloantibody without coexistent HLA antibodies successfully treated with antigen-negative platelet transfusions.