platelet neutralization procedure


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platelet neutralization procedure (PNP),

a technique based on the ability of platelets to bypass the effect of a lupus anticoagulant by correcting prolonged coagulation times in various phospholipid-dependent test systems; the disrupted platelet membranes in the freeze-thawed platelet suspension neutralize phospholipid antibodies in the plasma of patients with lupus anticoagulant; after the patient plasma is mixed with the freeze-thawed platelet suspension, the activated partial thromboplastin time will be corrected when compared with the original baseline activated partial thromboplastin time.

plate·let neut·ral·i·za·tion pro·ce·dure

(PNP) (plāt'lĕt nū'trăl-ī-zā'shŭn prŏ-sē'jŭr)
A technique based on the ability of platelets to bypass the effect of a lupus anticoagulant by correcting prolonged coagulation times in various phospholipid-dependent test systems; the disrupted platelet membranes in the freeze-thawed platelet suspension neutralize phospholipid antibodies in the plasma of patients with lupus anticoagulant; after the patient's plasma is mixed with the freeze-thawed platelet suspension, the activated partial thromboplastin time will be corrected when compared with the original baseline activated partial thromboplastin time.

platelet neutralization procedure

Abbreviation: PNP
A laboratory test to determine the presence of a lupus anticoagulant in a blood sample. The test is performed by adding platelet membranes to a plasma sample having a prolonged activated partial thromboplastin time (APTT). The normalization of the APTT after the addition of the platelet membranes suggests the presence of the anticoagulant.
See also: procedure
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