GP6

(redirected from platelet glycoprotein VI)

GP6

A gene on chromosome 19q13.4 that encodes a 58-kD platelet membrane glycoprotein, which plays a central role in the collagen-induced platelet activation and aggregation. Injury to the vessel wall and damage to the endothelial lining exposes the subendothelial matrix to blood flow, resulting in deposition of platelets. Collagen, especially types I, III and VI, are the most thrombogenic macromolecules of the extracellular matrix. The adhesion of platelets to collagen results in activation, leading to platelet secretion, recruitment of additional platelets and aggregation resulting in a platelet plug, which limits blood loss. However, collagen exposure after rupture of atherosclerotic plaques results in thrombus formation and may lead to myocardial infarction or stroke.
References in periodicals archive ?
Aegyptin will recognize and bind to specific platelet glycoprotein VI (GP VI), integrin [alpha]2[beta]1 and VWF (von Willebrand factor) so that the interaction between platelets and collagen will be prevented.
Aegyptin, a novel mosquito salivary gland protein specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin [alpha]2[beta]i and von Willebrand factor.
Platelet glycoprotein VI (GPVI) for early identification of acute coronary syndrome in patients with chest pain.
Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS).
Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke.
Effect of factor Xa, thrombin and new anticoagulants on human platelet glycoprotein VI (GPVI) expression and GPVI-mediated coagulation
This was accompanied by reduced tyrosine phosphorylation of the tyrosine kinase Syk and phospholipase Cgamma2, components of the platelet glycoprotein VI collagen receptor signaling pathway.
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