SERPINE1

(redirected from plasminogen-activator inhibitor 1)

SERPINE1

A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis.

Molecular pathology
SERPINE1 mutations cause plasminogen activator inhibitor-1 deficiency; high concentrations of the gene product are associated with thrombophilia.
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Included in an expanding range of preclinical research programmes are programmes targeting plasminogen-activator inhibitor 1 (PAI-1) in cancer and cardiovascular disease, the latter in collaboration with Lilly, and a late stage preclinical next generation topoisomerase inhibitor cytotoxic.
Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.
Conformational changes of the reactive-centre loop and beta-strand 5A accompany temperature-dependent inhib itor-substrate transition of plasminogen-activator inhibitor 1.