plasminogen activator inhibitor-1


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plas·min·o·gen ac·ti·va·tor in·hib·i·tor-1

(PAI-1) (plaz-min'ŏ-jen ak'ti-vā-tŏr in-hib'it-tŏr)
Peptide adipokine produced by visceral adipose tissue; has a regulatory role in fibrinolysis and thrombus formation.

plasminogen activator inhibitor-1

A protein that degrades extracellular tissues. It has been linked to the invasive and metastatic spread of cancers.
References in periodicals archive ?
Femoral and vertebral BMD, osteocalcin, pyrilinks D, beta-CrossLaps (B-CTx), insulin, C-reactive protein (CRP), fibrinogen and plasminogen activator inhibitor-1 (PAI-1) were measured in 114 postmenopausal female patients with diabetes type 2.
An increased production of pro-inflammatory molecules and a decrease in the fibrinolytic capacity has been described in the course of this pathology, which generally is attributed to in creased levels of plasminogen activator inhibitor-1 (PAI-1) (4-7).
Global Markets Direct's, 'Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1) - Pipeline Review, H1 2016', provides in depth analysis on Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1) targeted pipeline therapeutics.
Leading-edge myofibroblasts in human colon cancer express plasminogen activator inhibitor-1," American Journal of Clinical Pathology, vol.
Researchers from Boston's Brigham and Women's Hospital and Oregon Health and Science University have blamed the protein, plasminogen activator inhibitor-1 (PAI-1), for the increased risk for cardiovascular events in the morning.
The drug is made from the plasminogen activator inhibitor-1 (PAI-1), a natural inhibitor of tissue plasminogen activator (tPA).
Association of the plasminogen activator inhibitor-1 Gene 4G/5G polymorphism with ST elevation acute myocardial infarction in young patients.
This study was aimed to determine plasma levels of total (TFPI-T) and free (TFPI-F) tissue factor pathway inhibitor, plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (t-PA) in a cohort of Saudi patients with chronic stable angiographically defined coronary artery disease (CAD) and to determine its correlation with its severity.
An important rationale for this approach has been the observation that endothelium-derived nitric oxide (NO), a major mediator of endothelium-dependent vasodilation, has important anti-inflammatory and antithrombotic properties, ie, inhibiting leukocyte adhesion, limiting platelet adhesion and aggregation, and the expression of plasminogen activator inhibitor-1 (PAI-1), a prothrombotic protein.
Plasminogen activator inhibitor-1 and prognosis in primary breast cancer.
Objective: To compare levels of tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute myocardial infarction and unstable angina in order to understand the use of high sensitivity C-reactive protein (hsCRP), coagulation and fibrinolysis markers for cardiovascular risk assessment.

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