plasminogen activator


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Related to plasminogen activator: streptokinase, Plasminogen activator inhibitor

plasminogen activator

 [plaz-min´o-jen ak´tĭ-va″tor]
any of a group of substances that cleave plasminogen and convert it to plasmin, its active form, e.g., tissue plasminogen activator.

plas·min·o·gen ac·ti·va·tor

a proteinase converting plasminogen to plasmin by cleavage of an Arg-Val bond in the former.
Synonym(s): urokinase

plasminogen activator

/plas·min·o·gen ac·ti·va·tor/ (ak´tĭ-va″tor) see under activator.

plasminogen activator

the enzyme that converts plasminogen to plasmin. Also called tissue activator.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin by cleavage of a single (usually Arg-Val) bond in the former. Prevents formation of fibrin clots. Alteplase and streptokinase are examples of medications that promote thrombolysis by activating plasminogen.
Synonym(s): urokinase.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin and prevents formation of fibron clots.
Synonym(s): urokinase.

activator

a substance that makes another substance active or that renders an inactive enzyme capable of exerting its proper effect.

developing activator
see developing accelerator.
plasminogen activator
a substance that activates plasminogen and converts it into plasmin.
References in periodicals archive ?
Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator.
Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.
Wood bark smoke induces lung and pleural plasminogen activator inhibitor 1 and stabilizes its mRNA in porcine lung cells.
Plasminogen activator inhibitor-1 4G4G genotype is associated with myocardial infarction but not with stable coronary artery disease.
Cloning and expression of a human tissue plasminogen activator variant: [K.
Initially, several cross-sectional studies of patients with angina pectoris or previous myocardial infarction suggested that such patients had an impaired fibrinolytic system, and subsequently a few prospective cohort studies supported the notion that fibrinolytic factors such as plasminogen activator inhibitor (PAI-1) and tissue-type plasminogen activator (tPA) mass concentrations were predictors of future events in this type of patients.
Inmunohistochemical demonstration of the plasminogen activator system in human tissues and gingival fibroblasts.
Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset.
Studies regarding plasminogen activation in human cells have only used uPA (6,7), however, results from our lab suggest that tPA is the predominant plasminogen activator in humans (13).
This study's objective was to evaluate the clinical response and side effects of a thrombolytic agent, tissue plasminogen activator (tPA), for the treatment of ATE ("Prospective evaluation of tissue plasminogen activator in 11 cats with arterial thromboembolism" in the Journal of Feline Medicine and Surgery, 2010).

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