plasminogen activator


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Related to plasminogen activator: streptokinase, Plasminogen activator inhibitor

plasminogen activator

 [plaz-min´o-jen ak´tĭ-va″tor]
any of a group of substances that cleave plasminogen and convert it to plasmin, its active form, e.g., tissue plasminogen activator.

plas·min·o·gen ac·ti·va·tor

a proteinase converting plasminogen to plasmin by cleavage of an Arg-Val bond in the former.
Synonym(s): urokinase

plasminogen activator

/plas·min·o·gen ac·ti·va·tor/ (ak´tĭ-va″tor) see under activator.

plasminogen activator

the enzyme that converts plasminogen to plasmin. Also called tissue activator.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin by cleavage of a single (usually Arg-Val) bond in the former. Prevents formation of fibrin clots. Alteplase and streptokinase are examples of medications that promote thrombolysis by activating plasminogen.
Synonym(s): urokinase.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin and prevents formation of fibron clots.
Synonym(s): urokinase.

activator

a substance that makes another substance active or that renders an inactive enzyme capable of exerting its proper effect.

developing activator
see developing accelerator.
plasminogen activator
a substance that activates plasminogen and converts it into plasmin.
References in periodicals archive ?
Plasminogen activator inhibitor-1 4G4G genotype is associated with myocardial infarction but not with stable coronary artery disease.
Emodin upregulates urokinase plasminogen activator, plasminogen activator inhibitor-1 and promotes wound healing in human fibroblasts.
Tissue plasminogen activator in cardiac arrest with pulseless electrical activity.
Complications associated with the use of urokinase and recombinant tissue plasminogen activator for catheter-directed peripheral arterial and venous thrombolysis.
THR-18 corresponds to a fragment of plasminogen activator inhibitor-1 (PAI-1), a natural inhibitor of tPA.
Humphries S, Henney AM: The two allele sequences of a common polymorphism in promoter or the plasminogen activator inhibitor-1 (PA1-1) gene respond differently to imerlettkin-1 in HepG2 cells.
Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue.
However, repeated measures ANOVA showed that NONcNZO10 males maintained significantly higher plasma concentrations of two adipokines, resistin and plasminogen activator inhibitor-1, and the pro-inflammatory cytokine/adipokine macrophage chemoattractant protein-1.
Urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) are serine proteases that catalyse the conversion of a proenzyme, plasminogen, to active plasmin and play important roles in thrombolysis (Blasi et al.
A video feed allows the consultant to examine the patient, view the CT scan, and then decide if treatment with tissue plasminogen activator (tPA) is needed.

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