plasmin /plas·min/ (plaz´min) an endopeptidase occurring in plasma as plasminogen, which is activated via cleavage by plasminogen activators; it solubilizes fibrin clots, degrades other coagulation-related proteins, and can be activated for use in therapeutic thrombolysis.
plasmin.
plasmin (plaz´min),
plasmin
plas·min (pl z m n)n. An enzyme that hydrolyzes peptides and esters of arginine and histidine and converts fibrin to soluble products. Also called fibrinase, fibrinolysin. |
plasmin.
See fibrinolysin.
plasmin (plaz´min),
n collective term for one or more proteolytic enzymes found in the blood. The proteolytic enzymes are capable of digesting fibrin, fibrinogen, and proaccelerin. Plasminogen, the inactive form, may become active spontaneously in shed blood. An activator, fibrinokinase (fibrinolysokinase), is found in many animal tissues. Also called
fibrinolysin, lysin, plasma proteolytic enzyme, and
tryptase. See also plasminogen.
fibrinolysin, lysin, plasma proteolytic enzyme, and
tryptase. See also plasminogen.
plasmin
the active principle of the fibrinolytic or clot-lysing system, a proteolytic enzyme formed from plasminogen which hydrolyzes fibrin, fibrinogen, factor V and other proteins. It has the particular ability to dissolve formed fibrin clots. Called also fibrinolysin.
plasmin inhibitors
include α2-macroglobulin, α1-antitrypsin, C1-inactivator, antithrombin III.
plasmin
A proteolytic enzyme formed from plasminogen that lyses blood clots; plasmin exists in free and bound–fibrin-adsorbed forms; the former is destroyed as it is formed by antiplasmins, the latter acts as a serine endopeptidase to
solubilize fibrin clots; it hydrolyzes lysine and arginine bonds in certain proteins–eg, fibrinogen, coagulation factors V and VII. See tPA.
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