plasmin


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Related to plasmin: plasminogen, fibrinogen

plasmin

 [plaz´min]
the active principle of the fibrinolytic or clot-lysing system, a proteolytic enzyme with a high specificity for fibrin and the particular ability to dissolve formed fibrin clots.

plas·min

(plaz'min),
A serine proteinase catalyzing the hydrolysis of peptides and of esters of l-arginine and l-lysine and converting fibrin to soluble products; occurs in plasma as the precursor plasminogen (profibrinolysin) and is activated to plasmin by organic solvents, which remove an inhibitor, and by streptokinase, trypsin, and plasminogen activator, all cleaving a single arginyl-valyl bond; plasmin is responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin

plasmin

/plas·min/ (plaz´min) an endopeptidase occurring in plasma as plasminogen, which is activated via cleavage by plasminogen activators; it solubilizes fibrin clots, degrades other coagulation-related proteins, and can be activated for use in therapeutic thrombolysis.

plasmin

(plăz′mĭn)
n.
A proteolytic enzyme that is formed from plasminogen in blood plasma and dissolves the fibrin in blood clots. Also called fibrinolysin.

plasmin

plasmin

A proteolytic enzyme formed from plasminogen that lyses blood clots; plasmin exists in free and bound–fibrin-adsorbed forms; the former is destroyed as it is formed by antiplasmins, the latter acts as a serine endopeptidase to solubilize fibrin clots; it hydrolyzes lysine and arginine bonds in certain proteins–eg, fibrinogen, coagulation factors V and VII. See tPA.

plas·min

(plaz'min)
An enzyme hydrolyzing peptides and esters of l-arginine and l-lysine, and converting fibrin to soluble products; responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin.

plasmin

A protein-splitting enzyme in the blood that dissolves FIBRIN clots.

plasmin

enzyme formed from plasma fibrinogen; converts insoluble fibrin to soluble products, as part of clot lysis

plas·min

(plaz'min)
An enzyme responsible for the dissolution of blood clots.
Synonym(s): fibrinase (2) , fibrinolysin.

plasmin (plaz´min),

n collective term for one or more proteolytic enzymes found in the blood. The proteolytic enzymes are capable of digesting fibrin, fibrinogen, and proaccelerin. Plasminogen, the inactive form, may become active spontaneously in shed blood. An activator, fibrinokinase (fibrinolysokinase), is found in many animal tissues. Also called
fibrinolysin, lysin, plasma proteolytic enzyme, and
tryptase. See also plasminogen.

plasmin

the active principle of the fibrinolytic or clot-lysing system, a proteolytic enzyme formed from plasminogen which hydrolyzes fibrin, fibrinogen, factor V and other proteins. It has the particular ability to dissolve formed fibrin clots. Called also fibrinolysin.

plasmin inhibitors
include α2-macroglobulin, α1-antitrypsin, C1-inactivator, antithrombin III.
References in periodicals archive ?
28 In the presence of the lysine analogues, plasminogen can still be activated to plasmin, but it is inhibited from binding and degrading fibrin.
3] Nonstandard abbreviations: TF, tissue factor; FVIIa, activated factor VII; TM, thrombomodulin; PC, protein C; EPCR, endothelial protein C receptor; APC, activated PC; PS, protein S; AT, antithrombin; TFPI, tissue factor pathway inhibitor; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator; PAI, plasminogen activator inhibitor; PI, plasmin inhibitor; TAFI, thrombin activatable fibrinolysis inhibitor; ROTEM/TEG, thromboelastometry/thromboelastography; T2MR, T2 magnetic resonance.
The ability of Lpp to bind to plasminogen was tested by ELISA, and urokinase-plasminogen activation assays were done to confirm the conversion of Lpp-bound plasminogen to plasmin.
Plasmin is released into the blood in an inactive form called plasminogen.
Plasmin participates in fibrinolysis by degrading fibrin and in tissue remodeling by degrading extracellular matrix (ECM) and activating other matrix degrading proteases.
Blood monocytes detect the presence of oxidized lipoproteins and enter the vascular wall to become macrophages that secrete plasminogen activators to produce plasmin that activates procollagenases to produce collagenase that dissolves the damaged connective tissue in the vascular wall in preparation for replacement.
However, recognition that lysis of preformed fibrin could be accomplished in vivo by a process involving the conversion of inactive plasminogen to active plasmin enzyme led to an alternative enzyme-based approach.
Martin Milner, a naturopath at the Center for Natural Medicine in Portland, Oregon, found that nattokinase dissolves both fibrin and helps the body make more plasmin and other blood-dot busting substances.
The fibrinolytic pathway is involved with clot dissolution following the release of plasmin from plasminogen.
The virus thus has a ready source of plasmin, which it uses to cleave hemagglutinin.
It activates the fibrin-splitting enzyme, plasmin and dissolves fibrin clots (Fig 1).
Plasmin working by resolving fibrous protein in clots takes up a small market share while plasminogen activator represented by alteplase developed by Genentech is the mainstream product in global market.