Since CKD is predominantly a disease of the elderly so it is not rare to find the co-morbidities including plasmacytosis
, malignancies and their effects on the BM in patients of CKD.
12-15] Many of these studies highlight the difficulties in diagnosis of MM in HIV-positive patients, as the two diseases share some common clinical features, especially anaemia, fatigue, weight loss, bone marrow plasmacytosis
, renal insufficiency and recurrent bacterial infections.
These qualitative changes are helpful in distinguishing neoplastic plasma cell proliferations from reactive plasmacytosis
, which can present with significant plasmacytosis
Nonsteroidal antiinflammatory drug-induced ulcers are discrete, sharply demarcated mucosal defects bordered by normal mucosa on both sides, with no evidence of chronic features (architectural crypt distortion, basal plasmacytosis
, Paneth or pyloric metaplasia).
Stromal reactions of chronic inflammation and immune reaction in bone marrow include chronic granulomatous inflammation, reactive changes, plasmacytosis
, histiocytic hyperplasia, chronic inflammation with fibrosis and amyloidosis.
The megakaryoblasts were markedly reduced with reactive plasmacytosis
Patient 1 had a 2-yr history of hematuria, proteinuria and renal insufficiency and a bone marrow biopsy showed 15% clonal plasmacytosis
Prior to the development and use of effective ART, HIV patients commonly developed bone marrow pathologies, including dysplasia, impaired erythropoiesis, plasmacytosis
, and lymphocytic infiltration into the marrow compartment (Calenda et al.
Specific clinical parameters have been identified by Oksenhendler  to increase the rate of diagnosing Castleman's disease in HIV-positive individuals, including fever, diffuse lymphadenopathy, splenomegaly, severe cytopenia, high serum C-reactive protein levels, elevated HHV-8 DNA levels in peripheral blood mononuclear cells, extreme plasmacytosis
in lymph nodes or bone marrow, nasal obstruction, respiratory symptoms, Kaposi's sarcoma lesions, a previous similar episode with spontaneous resolution, positive Coombs' test and haemophagocytic syndrome.
It updates diagnostic criteria and management options for all diseases; adds new chapters and new entities; and adds data on primary cutaneous T-follicular helper-cell lymphoma, intralymphatic CD30+ anaplastic large cell lymphoma, cutaneous manifestations in extracavity primary effusion lymphoma and Burkitt lymphoma, cutaneous plasmablastic lymphoma, pseudolymphomatous acrodermatitis chronica atrophicans, pseudolymphomatous atopic dermatitis, non-neoplastic erythroderma in adult patients, Epstein-Barr virus-associated mucocutaneous ulcers, cutaneous IgG4-related disease, cutaneous and systemic plasmacytosis
, benign intralymphatic proliferation of T-cell lymphoid blasts, and other conditions and disease variants.
A biopsy and bone marrow aspiration were performed, and a marrow cytological examination showed a decrease in marrow hyperplasia with rouleau formation, but there was normal morphology of the red blood cells along with plasmacytosis
Microscopically, the ileum and colon mucosa presented preserved architecture without cryptitis or basal plasmacytosis