plasma volume

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the space occupied by a substance or a three-dimensional region; the capacity of such a region or of a container.
blood volume the plasma volume added to the red cell volume; see also blood volume.
closing volume (CV) the volume of gas in the lungs in excess of the residual volume at the time small airways in the dependent portions close during maximal exhalation; see also closing volume.
deficient fluid volume a nursing diagnosis accepted by the North American Nursing Diagnosis Association, defined as decreased intravascular, interstitial, and/or intracellular fluid. This refers to dehydration, water loss alone without change in sodium. See also fluid volume. Formerly called fluid volume deficit.

When a person engages in normal physical activity and the environmental temperature is 20°C (68°F), the body loses about 2400 ml of water in 24 hours. About 1400 ml are lost in urine, 200 ml in feces, and 100 ml in sweat. The remaining 700 ml are lost through what is called insensible water loss, which takes place by diffusion through the skin and by evaporation from the lungs. About 300 ml of water diffuse through the epithelial cells daily. The lungs excrete about 400 ml per day.

A deficit of fluid volume occurs when there is either an excessive loss of body water or an inadequate compensatory intake. Etiologic factors include active loss through vomiting, diarrhea, gastric suctioning, drainage through operative wounds and tubes, burns, fistulas, hypermetabolic states, and drug-induced diuresis. Insufficient intake of water can be caused by nausea, immobility with inaccessibility of water, and lack of knowledge about the necessity of adequate fluid intake.
Patient Care. Assessment of the patient's hydration status includes monitoring lab data for such signs as increased packed red blood cell volume, increased plasma protein level, elevated specific gravity of urine, and increased blood urea nitrogen (BUN) out of proportion to a change in serum creatinine. In the absence of other problems, the serum sodium should remain within normal limits.

Recording daily weight gives information about the amount of water gained or lost each day. If there is a fluid volume deficit, intake and output measurements can give evidence of fluid imbalance. The urine appears concentrated and is usually well below the criterion of 50 ml of output per hour. Other objective assessment data include hypotension and a decrease in venous filling and in pulse volume and pressure. The mucous membranes are dry, as is the skin, which loses its turgor. The patient may complain of thirst and the body temperature may be elevated.

Patients at risk for profound and potentially fatal fluid volume deficit, as in severe burns, should be assessed frequently for mental acuity status and orientation to person, place, and time. Measures to improve hydration status should take into account the patient's ability to drink and retain fluids by mouth, preferences for certain fluids, and whether hot or cold drinks are preferred. The goal of oral fluid intake should be about 2000 ml per day. Explanations about the importance of an adequate fluid intake and assuring the availability of fresh water and fluids attractive to the patient can help reach the desired goal. Intravenous administration of fluids, especially isotonic saline, may be necessary if oral replacement is not possible. In severe and intractable fluid volume deficit a central venous catheter may be used to evaluate the extent of fluid loss and to guide replacement therapy.
excess fluid volume a nursing diagnosis accepted by the North American Nursing Diagnosis Association, defined as increased isotonic fluid retention; see also fluid volume. Factors contributing to this include (1) arterial dilatation, as occurs in the inflammatory process; (2) reduced oncotic pressure, as in hypoproteinuria (particularly a deficit of albumin, which is responsible for 80 per cent of oncotic pressure), lymphatic obstruction, and increased capillary permeability, which allows water to escape into the tissues and produce swelling; (3) renal retention of sodium and consequently of water, as seen in renal failure; (4) inadequate circulation of blood through the general circulation, as in congestive heart failure, or through the portal circulation, as in liver failure; and (5) overproduction or administration of adrenocortical hormones.

Hypervolemia can occur when a patient receives excessive fluid replacement or repeated tap water enemas or, much less frequently, drinks more fluids than are eliminated. Characteristics of fluid volume excess include obvious swelling, localized or generalized; weight gain; pulmonary congestion with accompanying shortness of breath, orthopnea, and abnormal breath sounds; a fluid intake greater than output; distended neck veins; and changes in central venous and pulmonary artery pressures.
expiratory reserve volume the maximal amount of gas that can be exhaled from the resting end-expiratory level.
fluid volume the volume of the body fluids, including both intracellular fluid and extracellular fluid.
forced expiratory volume (FEV) the volume that can be exhaled from a full inhalation by exhaling as forcefully and rapidly as possible for a timed period. Times are denoted by subscripts, such as FEV0.5, FEV1.0, FEV2.0, and FEV3.0 for FEV values for 0.5, 1, 2, and 3 seconds.
inspiratory reserve volume the maximal amount of gas that can be inhaled from the end-inspiratory position.
mean corpuscular volume (MCV) the average volume of erythrocytes, conventionally expressed in cubic micrometers or femtoliters (μm3 = fL) per red cell, obtained by multiplying the hematocrit (in l/L) by 1000 and dividing by the red cell count (in millions per μL): MCV = Hct/RBC. Automated electronic blood cell counters generally obtain the MCV directly from the average pulse height of the voltage pulses produced during the red cell count. These instruments obtain the hematocrit indirectly from the equation Hct = MCV × RBC.
minute volume (MV) the quantity of gas exhaled from the lungs per minute; tidal volume multiplied by respiration rate.
packed-cell volume (PCV) hematocrit.
plasma volume the total volume of blood plasma, i.e., the extracellular fluid volume of the vascular space; see also blood volume.
red cell volume the total volume of red cells in the body; see also blood volume.
residual volume (RV) the amount of gas remaining in the lung at the end of a maximal exhalation.
risk for deficient fluid volume a nursing diagnosis accepted by the North American Nursing Diagnosis Association, defined as being at risk for vascular, cellular, or intracellular dehydration. See also deficient fluid volume.
stroke volume the quantity of blood ejected from a ventricle at each beat of the heart; called also stroke output.
tidal volume the amount of gas passing into and out of the lungs in each respiratory cycle.

plasma volume

the total volume of plasma in the body, elevated in diseases of the liver and spleen and in vitamin C deficiency and lowered in Addison's disease, dehydration, and shock. The normal plasma volume in males is 39 mL/kg of body weight; in females, 40 mL/kg.

plasma volume

The total quantity of plasma in the body. It decreases with dehydration and increases with greater salt and water intake and during early pregnancy. Plasma volume can be measured with injected fluorescent-labeled albumin.
See also: volume


the fluid portion of the blood in which corpuscles are suspended. Plasma is to be distinguished from serum, which is plasma from which the fibrinogen has been separated in the process of clotting.

plasma bound
many electrolytes exist in plasma in a form in which they are bound to protein which reduces their lability and liability to loss in the urine, e.g. protein-bound iodine.
plasma cell gingitivitis-pharyngitis
see feline plasma cell gingivitis-pharyngitis.
plasma cell myeloma
see multiple myeloma.
plasma cell pododermatitis
a nonpainful swelling with ulceration and exuberant granulation tissue on the footpads of cats. The cause is unknown but believed to be immunological.
Enlarge picture
Plasma cell pododermatitis in a cat.
plasma clearing factor
a lipoprotein lipase which lipolyses the triglyceride in the chylomicrons of the plasma and hence clears it of cloudiness.
plasma exchange
the removal of plasma from withdrawn blood (plasmapheresis) and retransfusion of the formed elements and type-specific fresh-frozen plasma into the donor; done for removal of circulating antibodies or abnormal plasma components.
plasma expanders
see plasma volume expander.
fresh-frozen plasma
prepared from whole blood; a source of coagulation factors.
plasma protein
the heterologous group of proteins in circulating blood that includes albumin, lipoproteins, glycoproteins, transcortin, haptoglobin, ceruloplasmin, cholinesterase, α2-macroglobulin, erythropoietin, transferrin, hemopexin, fibrinogen, plasminogen and the immunoglobulins (γ-globulins).
plasma protein:fibrinogen (PP:F) ratio
an indicator of significant changes in fibrinogen levels, taking into account dehydration.
plasma substitute
a fluid suitable for use as a replacement for plasma in the animal body. Usually a solution of gelatin or dextran.
therapeutic plasma concentration
a therapy-response relationship determined only by experiment; the plasma level which is matched by the desired therapeutic response.
plasma thromboplastin antecedent
clotting factor XI; see plasma thromboplastin antecedent.
plasma turbidity test
a qualitative test for fat absorption, performed by comparing the turbidity of plasma before and 2, 3 and 4 hours after the oral administration of fats, usually vegetable oil. Results are greatly influenced by delays in gastric emptying, so normally this test can only be relied upon to rule out malabsorption or maldigestion when evidence of absorption is found.
plasma volume
the estimation of plasma volume is essential to a complete knowledge of a patient's fluid status. The common technique is by the intravenous injection of a known amount of a dye such as Evans blue and the subsequent measurement of the dilution that it has undergone in a set time period.
References in periodicals archive ?
As establishment of normal pregnancy reference ranges appears imminent, clinical laboratory scientists may do well to consider the total plasma volume (differences) between normal pregnant and PE patients that result in hemodilution and relative hemoconcentration.
In the NI control of the present experiment, a decrease in plasma volume estimated by increases in hematocrit and plasma total protein concentrations was apparent within 15 min of the commencement of feeding (Figure 3).
The role of osmolality and plasma volume during rehydration in humans.
Together, low plasma volume and high cholesterol were associated with a 3.
The global plasma volume in 2012 exceeded 30,000 tons and the market scale reached USD 17.
This "sports anemia" has been attributed to a physiologic response to exercise due to expansion of plasma volume that dilutes red blood cells.
Australia is a very important territory for Volplex as it is both a major market for plasma volume replacement therapy in its own right and also a gateway to the important countries of the Pacific region.
SPECIALIST healthcare products company Maelor, which is based in Wrexham, has signed an exclusive distribution agreement for the sale of its blood plasma volume substitute Volplex in sub-Saharan Africa.
In 2012, China blood product enterprises realized a total plasma volume of 3,300 tons which decreased compared with that in 2011.
As new plasma stations have been gradually put into operation since 2011, the plasma volume is expected to recover in 2013 and gradually reach 3,520 tons in 2011.
In August 2011, China shut down 16 plasma stations in Guizhou, resulting in a decrease of 15% in the plasma volume of the year.