plasma substitute

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plas·ma sub·sti·tute

a solution of a substance (for example, dextran) used for transfusion in hemorrhage or shock as a substitute for plasma.
Synonym(s): plasma expander

plas·ma sub·sti·tute

(plazmă substi-tūt)
A solution of a substance (e.g., dextran) used for transfusion after hemorrhage or shock as a substitute for plasma.
Synonym(s): plasma expander.


the fluid portion of the blood in which corpuscles are suspended. Plasma is to be distinguished from serum, which is plasma from which the fibrinogen has been separated in the process of clotting.

plasma bound
many electrolytes exist in plasma in a form in which they are bound to protein which reduces their lability and liability to loss in the urine, e.g. protein-bound iodine.
plasma cell gingitivitis-pharyngitis
see feline plasma cell gingivitis-pharyngitis.
plasma cell myeloma
see multiple myeloma.
plasma cell pododermatitis
a nonpainful swelling with ulceration and exuberant granulation tissue on the footpads of cats. The cause is unknown but believed to be immunological.
Enlarge picture
Plasma cell pododermatitis in a cat.
plasma clearing factor
a lipoprotein lipase which lipolyses the triglyceride in the chylomicrons of the plasma and hence clears it of cloudiness.
plasma exchange
the removal of plasma from withdrawn blood (plasmapheresis) and retransfusion of the formed elements and type-specific fresh-frozen plasma into the donor; done for removal of circulating antibodies or abnormal plasma components.
plasma expanders
see plasma volume expander.
fresh-frozen plasma
prepared from whole blood; a source of coagulation factors.
plasma protein
the heterologous group of proteins in circulating blood that includes albumin, lipoproteins, glycoproteins, transcortin, haptoglobin, ceruloplasmin, cholinesterase, α2-macroglobulin, erythropoietin, transferrin, hemopexin, fibrinogen, plasminogen and the immunoglobulins (γ-globulins).
plasma protein:fibrinogen (PP:F) ratio
an indicator of significant changes in fibrinogen levels, taking into account dehydration.
plasma substitute
a fluid suitable for use as a replacement for plasma in the animal body. Usually a solution of gelatin or dextran.
therapeutic plasma concentration
a therapy-response relationship determined only by experiment; the plasma level which is matched by the desired therapeutic response.
plasma thromboplastin antecedent
clotting factor XI; see plasma thromboplastin antecedent.
plasma turbidity test
a qualitative test for fat absorption, performed by comparing the turbidity of plasma before and 2, 3 and 4 hours after the oral administration of fats, usually vegetable oil. Results are greatly influenced by delays in gastric emptying, so normally this test can only be relied upon to rule out malabsorption or maldigestion when evidence of absorption is found.
plasma volume
the estimation of plasma volume is essential to a complete knowledge of a patient's fluid status. The common technique is by the intravenous injection of a known amount of a dye such as Evans blue and the subsequent measurement of the dilution that it has undergone in a set time period.
References in periodicals archive ?
Gelatin-based plasma substitutes are denatured collagens and thus contain complex mixtures of proteins (4).
They already have experience of selling plasma substitute therapies and estimate that the Bangladesh market is of a similar size to the UK,at around pounds 9m.
Shares in the healthcare company jumped 12pc in early trading yesterday as the group launched the blood plasma substitute to treat patients with severe blood loss.
Revenue came from sales of catheter maintenance system OptiFlo into the highly competitive UK market where it has now secured a 26pc share and from blood plasma substitute intermediate product Volplex which is sold in the Middle East.
The company, which has offices at Newbridge, near Wrexham, has also announced the completion of arrangements for the local manufacture in Iran of a version of its plasma substitute Volplex/ Gelplex.
The company believes it is close to winning full approval for its colloid plasma substitute Volplex after responding to a further round of questions raised by the Medicines Control Agency.
Tenders are invited for Blood plasma substitutes and infusion solutions
In reply to a question, he said rational use of blood components in the management of bleeding disorders was extremely important and efforts are underway for developing guidelines for use of blood/ plasma substitutes.
Interference by gelatin-based plasma substitutes in capillary zone electrophoresis.
Contract award notice: Antineoplastic and blood plasma substitutes and solutions for infusions.

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