plasma cell myeloma

myeloma /my·elo·ma/ (mi″ĕ-lo´mah) a tumor composed of cells of the type normally found in the bone marrow.

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giant cell myeloma  see under tumor (1).

multiple myeloma  a disseminated type of plasma cell dyscrasia characterized by multiple bone marrow tumor foci and secretion of an M component, manifested by skeletal destruction, pathologic fractures, bone pain, the presence of anomalous circulating immunoglobulins, Bence Jones proteinuria, and anemia.

plasma cell myeloma  multiple m.

sclerosing myeloma  myeloma associated with osteosclerosis, most often manifested by peripheral neuropathy.

solitary myeloma  a variant of multiple myeloma in which there is a single localized tumor focus.

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plasma cell myeloma

n.

A malignant plasmacytoma of bone.

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plasma cell myeloma.

See multiple myeloma.

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myeloma (mī´lō´m),

n a neoplasm characterized by cells normally found in the bone marrow.

myeloma, multiple,

n a primary malignant neoplasm of bone marrow characterized by proliferation of cells resembling plasma cells. Circumscribed radiolucencies are seen within the bones, and Bence Jones protein is usually found in the urine.

Multiple myeloma.

myeloma, plasma cell,

n a malignant neoplasm characterized by plasma cells. Solitary lesions may appear as radiolucencies in the bone and are sometimes considered benign, although most authorities believe that even these lesions become multiple and terminate fatally.

myeloma, solitary plasma cell,

n an incompletely understood monostotic neoplasm of bone that is histologically identical with multiple myeloma. Laboratory findings, positive in multiple myeloma, are usually negative in solitary plasma cell myeloma. Although usually benign, solitary plasma cell myelomas may be malignant.

myelomeningocele

(mī´lōmning´gōsēl),
n a condition in which part of the spinal cord protrudes from between the bones of the vertebrae. The condition can result in paralysis.

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myeloma

1. a B lymphocyte tumor.

2. multiple myeloma.

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giant cell myeloma

giant cell tumor (1).

multiple myeloma

a malignant neoplasm of plasma cells, in which the plasma cells proliferate and invade the bone marrow, causing destruction of the bone and resulting in pathological fracture and bone pain. A secretory form of the disease is characterized by the presence of an immunoglobulin recognized as Bence Jones protein (monoclonal immunoglobulin), Bence Jones proteinuria, anemia, and lowered resistance to infection. It is the most common type of monoclonal gammopathy. A non-secretory form of the disease also occurs.

osteosclerotic myeloma

multiple myeloma associated with osteosclerosis (rather than bone destruction) and often with peripheral neuropathy.

plasma cell myeloma

see multiple myeloma (above).

myeloma protein

the immunoglobulin molecules produced by myeloma cells. See gammopathy.

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plasma

the fluid portion of the blood in which corpuscles are suspended. Plasma is to be distinguished from serum, which is plasma from which the fibrinogen has been separated in the process of clotting.

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plasma bound

many electrolytes exist in plasma in a form in which they are bound to protein which reduces their lability and liability to loss in the urine, e.g. protein-bound iodine.

plasma cell gingitivitis-pharyngitis

see feline plasma cell gingivitis-pharyngitis.

plasma cell myeloma

see multiple myeloma.

plasma cell pododermatitis

a nonpainful swelling with ulceration and exuberant granulation tissue on the footpads of cats. The cause is unknown but believed to be immunological.

Plasma cell pododermatitis in a cat.

plasma clearing factor

a lipoprotein lipase which lipolyses the triglyceride in the chylomicrons of the plasma and hence clears it of cloudiness.

plasma exchange

the removal of plasma from withdrawn blood (plasmapheresis) and retransfusion of the formed elements and type-specific fresh-frozen plasma into the donor; done for removal of circulating antibodies or abnormal plasma components.

plasma expanders

see plasma volume expander.

fresh-frozen plasma

prepared from whole blood; a source of coagulation factors.

plasma protein

the heterologous group of proteins in circulating blood that includes albumin, lipoproteins, glycoproteins, transcortin, haptoglobin, ceruloplasmin, cholinesterase, α₂-macroglobulin, erythropoietin, transferrin, hemopexin, fibrinogen, plasminogen and the immunoglobulins (γ-globulins).

plasma protein:fibrinogen (PP:F) ratio

an indicator of significant changes in fibrinogen levels, taking into account dehydration.

plasma substitute

a fluid suitable for use as a replacement for plasma in the animal body. Usually a solution of gelatin or dextran.

therapeutic plasma concentration

a therapy-response relationship determined only by experiment; the plasma level which is matched by the desired therapeutic response.

plasma thromboplastin antecedent

clotting factor XI; see plasma thromboplastin antecedent.

plasma turbidity test

a qualitative test for fat absorption, performed by comparing the turbidity of plasma before and 2, 3 and 4 hours after the oral administration of fats, usually vegetable oil. Results are greatly influenced by delays in gastric emptying, so normally this test can only be relied upon to rule out malabsorption or maldigestion when evidence of absorption is found.

plasma volume

the estimation of plasma volume is essential to a complete knowledge of a patient's fluid status. The common technique is by the intravenous injection of a known amount of a dye such as Evans blue and the subsequent measurement of the dilution that it has undergone in a set time period.

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Patient discussion about plasma cell myeloma.

Q. Multiple Myeloma what and how is it treated and what is MGUF

A. Were you referring by any chance to MGUS (monoclonal gammopathy of unknown significance)? It's a condition that resembles myeloma but is much more widespread and by itself isn't considered malignant. It may, however, deteriorate to multiple myeloma over the years.

Myeloma is treated with chemotherapy of various kinds, and sometimes with bone marrow transplantation with the patients own bone marrow.

You may read more here:
www.nlm.nih.gov/medlineplus/multiplemyeloma.html