plasma cell dyscrasia

plas·ma cell dys·cra·si·a

A diverse group of diseases characterized by the proliferation of a single clone of cells producing a monoclonal immunoglobulin or immunoglobulin fragment (a serum M component). The cells usually have plasma cell morphology, but may have lymphocytic or lymphoplasmacytic morphology. This group includes multiple myeloma, Waldenström macroglobulinemia, the heavy chain disease, benign monoclonal gammopathy, and immunocytic amyloidosis.

plasma cell dyscrasia

A lymphoproliferative disorder characterized by monoclonal proliferation of plasma cells, with clinical behavior ranging from innocuous extramedullary plasmacytomas to premalignant solitary plasmacytoma of bone to myeloma. Cf Monoclonal gammopathy of undetermined significance, Myeloma.
References in periodicals archive ?
POEMS syndrome is a underlying plasma cell dyscrasia related paraneoplastic syndrome and CD is one of the major criteria in the diagnosis of this disease.
At this time she is considered to have a monoclonal B cell lymphocytosis with the immunophenotype of chronic lymphocytic leukemia/lymphoma and a plasma cell dyscrasia that may represent monoclonal gammopathy of uncertain significance.
What type of plasma cell dyscrasia is associated with these results?
In addition, SLE and SS are also associated with some plasma cell dyscrasias, such as monoclonal gammopathy of undetermined significance, macroglobulinemia, and amyloidosis; however, multiple myeloma (MM) as a lymphoproliferative neoplasm and plasma cell dyscrasia are not nearly as common.
Most cases of plasma cell dyscrasia are diagnosed without Flow cytometry; however, it may be useful in certain patients with hematologic abnormalities and an elevated level of plasma cells in the bone marrow and without specific clinical manifestations (3).
Isolated acquired FX deficiency raises the possibility of amyloidosis which is most commonly a complication of an underlying plasma cell dyscrasia.
The patient returned to the Otolaryngology Clinic 3 weeks after the diagnosis of her plasma cell dyscrasia.
Systemic light-chain (AL) amyloidosis is a clonal plasma cell dyscrasia.
The underlying bone marrow disorder/monoclonal immunoglobulin producing disorder is known by many different names (plasma cell disorder, plasma cell dyscrasia, paraprotein disorder, monoclonal gammopathy, etc), and is very subtle in 80% of patients.
Bone marrow biopsy revealed a plasma cell dyscrasia with 10% plasma cells.
Multiple myeloma is the second most common haematological malignancy after Non-Hodgkin's Lymphoma and is part of a spectrum of diseases labelled Plasma Cell Dyscrasia.
Immunoglobulins (paraproteins) -- Elevated in plasma cell dyscrasia such as multiple myeloma and Waldenstrom's macroglobulinemia.