A class of intermediate filament-binding proteins that act in linking keratin filaments to hemidesmosomes in epithelial cells as well as neurofilaments to actin in neurons. Moreover, in many cells they also find intermediate filaments, actin, and microtubules to each other, assisting in the formation of a three-dimensional lattice of cytoskeletal elements.
See also: hemidesmosomes, cytoskeleton.
[G. plakoō, to cover with plates, + -in]
References in periodicals archive ?
Other molecules studied by [150] are plakins, which represent a family of molecules which form the links between filaments, desmosomes, and hemidesmosomes and plectin is a cytolinker of this family.
Further, Tamara Plakins Thornton in Handwriting in America: A Cultural History (1996, p.