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A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.


Abbreviation for Peutz-Jeghers syndrome.
References in periodicals archive ?
After PJ's death, ATC's production manager sent me and the cast a video that PJ shot of us an hour before The Humans's opening night curtain.
The setting for the commercial is inside PJ's Pub and Grill event space.
I knew PJ's financial support had been stopped pending enquiries and I thought this was an outrage," she said.
I can only hope PJ's death will show other kids what can happen, how dangerous knives are.
PJ's life has always revolved around music, especially rock music.
The note-writing, the search for a new best friend, and her dramatic declaration that she is "never going to apologize" make PJ's distress believable.
The PJ's emphasis on the role of courts as protectors of the individual and his unique empathy, illustrated so vividly in his dissents, are also on display in what the PJ considers one of his signature decisions, Matter of Matthews.
Jennifer and Paul Jarvis, the owners of PJ's Hotel, say they have made St Oswald's Hospice an offer they cannot refuse.
We are grateful to all PJ's close friends who visited him during his illness, to our kind neighbours for their support and to the Irish Racehorse Trainers' Association.
And, despite PJ's capacious footprint (20,000-plus square feet in all), first time visitors can be forgiven for not immediately noticing the gem of a store they've entered.
Buy a PJ's Coffee of New Orleans franchise for less than half the price in Naples, FL.
Generous customers at PJ's Hotel and Restaurant, in Percy Main, North Shields, have been digging deep and donating their spare change since bar bosses put a collection tin for the Great North Air Ambulance on display.