Clinical and bacteriological outcome of different doses and duration of pivmecillinam
compared with placebo therapy of uncomplicated lower urinary tract infection in women: the LUTIW project.
Because antimicrobial treatment of cystitis typically is motivated by concern for patient's comfort, withholding treatment or the promotion of pivmecillinam
as a first-line antimicrobial drug should seriously be considered.
22) Although WHO recommends ceftriaxone, pivmecillinam
and azithromycin for shigellosis due to the increase in fluoroquinolone resistant shigellae, the species was found to be resistant to one of the third generation cephalosporins and azithromycin.
Carnitine deficiency induced by pivampicillin and pivmecillinam
Emergence of fluoroquinolone resistance has limited the number of antibiotics, like ceftriaxone, azithromycin, and pivmecillinam
for use in shigellosis.
is the prodrug which releases the active agent mecillinam when absorbed.
In women, first-generation cephalosporins and sulphatrimethoprim were most common in all age groups, but pivmecillinam
was also frequently prescribed to those aged 85 years or over.
the Swedish NordDRG, and assuming UTI treatment with pivmecillinam
, 200 mg 3 times per day for 5 days as a first fine treatment), the median total annual cost of catheter-related infections and complications per patient could be estimated to be 662 [euro] (mean 1,180 [euro], range 0 [euro] to 12,277 [euro]), corresponding to approximately $738 USD (mean $1,315 USD; range $0 to $13,689).
In addition, ceftriaxone, pivmecillinam
(amdinocillin pivoxil), and azithromycin are also considered alternative drugs suitable for the treatment of Shigella-associated disease (14).
For this reason, the World Health Organization recommends that all patients with bloody diarrhea be treated with either ciprofloxacin or 1 of the 3 second-line drugs: pivmecillinam
, azithromycin, and ceftriaxone (7).
or ciprofloxacin might be considered for treating shigellosis with caution.
Randomised comparison of ciprofloxacin suspension and pivmecillinam
for childhood shigellosis.