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pituitary apoplexy |
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pituitary apoplexy Acute life-threatening hemorrhagic infarction of the anterior pituitary or adenohypophysis, often associated with an infarcted pituitary adenoma or other tumor; PA may occur spontaneously, or due to an
'obstetric' hemorrhage–eg, Sheehan syndrome, regional RT, ↑ intracranial pressure, or systemic anticoagulation Clinical The PA 'syndrome' may be transient or permanent; it is characterized by sudden headache, loss
of vision, ophthalmoplegia, and if severe, shock Lab ↓ Growth hormone, ↓ gonadotropins, ↓ ACTH, ↓ TSH–with hypothyroidism, abnormal prolactin secretion, rarely, diabetes insipidus Treatment Hormone replacement,
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