The pituicytoma, or infundibuloma, is a rare tumor of the sellar region that displays a spindle cell morphology, fascicular arrangement of tumor cells, and variable glial fibrillary acidic protein (GFAP) immunoreactivity.
3-5) In this study, we present the histologic, immunohistologic, and ultrastructural features of 2 cases of pituicytoma and demonstrate genomic copy number imbalances associated with this unique neoplasm by using array-based comparative genomic hybridization (array CGH).
During a 6-year period between the years 2000 and 2006, 2 patients underwent resection of a sellar mass with a pathologic diagnosis of pituicytoma at the University of California, San Francisco.
The pituitary adenomas also contained various chromosomal imbalances; however, these were distinct from those identified in the pituicytoma (data not shown).
The pituicytoma is a rare neoplasm of the sellar region.
Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma
We report a case of pituicytoma and compare its immunophenotypic characteristics with those of normal neurohypophysis and other low-grade spindled lesions of the sellar compartment.
The immunohistochemical features of this tumor supported the diagnosis of pituicytoma over the other entities.
Although granular cell tumors (also referred to as choristomas and granular cell myoblastomas) and pituicytomas are low grade and may have a shared histogenesis, they represent 2 distinct lesions pathologically, and we prefer reserving the designation pituicytoma for low-grade spindled lesions.
A report of a granular cell pituicytoma associated with multiple endocrine neoplasia type 2 is in the literature; however, this tumor is an example of a granular cell tumor or granular cell myoblastoma.
However, the histogenesis of these tumors is controversial, evident by various terms in the literature that have attempted to describe GCT, including choristoma, tumorlet, myoblastoma, and pituicytoma.
4,5,6,9] The relationship, however, between the histogenesis of GCT and pituicytoma, a distinctive low-grade glioma of the neurohypophysis, remains controversial.